| Gene Symbol |
HSD17B11
|
| Entrez Gene |
51170
|
| Alt Symbol |
17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxysteroid (17-beta) dehydrogenase 11
|
| Other Description |
17-beta-hydroxysteroid dehydrogenase type XI|CTCL tumor antigen HD-CL-03|CTCL-associated antigen HD-CL-03|cutaneous T-cell lymphoma-associated antigen HD-CL-03|dehydrogenase/reductase SDR family member 8|estradiol 17-beta-dehydrogenase 11|retinal short-chain dehydrogenase/reductase 2|short chain dehydrogenase/reductase family 16C member 2|short chain dehydrogenase/reductase family 16C, member 2
|
| Swissprots |
Q9UKU4 Q8NBQ5 Q96HF6
|
| Accessions |
AAL48315 EAX05987 Q8NBQ5 AF126780 AAF06939 AF273056 AAM44459 AK075348 BAC11560 AY358553 AAQ88917 BC008650 AAH08650 BC011995 BC014327 AAH14327 BC016367 AAH16367 BC021673 AAH21673 BC036001 AAH36001 BM976691 BU838518 CA775960 CB163647 DA265697 XM_006714232 XP_006714295 XM_011532021 XP_011530323 NM_016245 NP_057329
|
| Function |
Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. {ECO:0000269|PubMed:10800688, ECO:0000269|PubMed:11165019, ECO:0000269|PubMed:12697717, ECO:0000269|PubMed:9888557}.
|
