| Gene Symbol |
PPP1R12B
|
| Entrez Gene |
4660
|
| Alt Symbol |
MYPT2, PP1bp55
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 12B
|
| Other Description |
myosin phosphatase target subunit 2|myosin phosphatase, target subunit 2|myosin phosphatase-targeting subunit 2|protein phosphatase 1 regulatory subunit 12B|protein phosphatase 1, regulatory (inhibitor) subunit 12B
|
| Swissprots |
A8MYF5 Q9HCB7 Q5T506 Q9HCB8 Q2TAI8 Q8N179 O60237 B7ZMN6 Q5VUK2
|
| Accessions |
AAK00336 EAW91416 EAW91417 EAW91418 EAW91419 EAW91420 EAW91421 EAW91422 EAW91423 EAW91424 EAW91425 O60237 AB003062 BAA28376 AB007972 AB050641 BAB17610 AB050642 BAB17611 AB588820 BAJ22080 AF324888 AAK00337 AK025291 AK098261 AK307591 AL049388 AL050133 AL117460 BC034430 AAH34430 BC071166 AAH71166 BC110907 AAI10908 BC144699 AAI44700 BX501884 DA075060 XM_005245206 XP_005245263 XM_011509573 XP_011507875 XM_011509574 XP_011507876 XM_011509575 XP_011507877 XM_011509576 XP_011507878 XM_011509577 XP_011507879 XM_011509578 XP_011507880 NM_001167857 NP_001161329 NM_001167858 NP_001161330 NM_001197131 NP_001184060 NM_002481 NP_002472 NM_032103 NP_115286 NM_032104 NP_115287 NM_032105
|
| Function |
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12923170}. Note=Along actomyosin filaments and stress fibers.
|
| Tissue Specificity |
Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
|
| Top Pathways |
Focal adhesion, Vascular smooth muscle contraction, Oxytocin signaling pathway, Proteoglycans in cancer, Regulation of actin cytoskeleton
|
