Gene Symbol | VCPIP1 |
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Entrez Gene | 80124 |
Alt Symbol | DUBA3, VCIP135 |
Species | Human |
Gene Type | protein-coding |
Description | valosin containing protein (p97)/p47 complex interacting protein 1 |
Other Description | VCP/p47 complex-interacting 135-kDa protein|deubiquitinating protein VCIP135|valosin-containing protein (p97)/p47 complex-interacting protein p135|valosin-containing protein p97/p47 complex-interacting protein 1|valosin-containing protein p97/p47 complex-interacting protein p135 |
Swissprots | Q8N3A9 Q86W01 Q96JH7 Q9H5R8 Q504T4 Q86T93 |
Accessions | EAW86916 Q96JH7 AB058753 BAB47479 AK026785 BAB15552 AK225580 AK297345 BAG59796 AL832606 CAD89944 AL834476 CAD39135 AM392649 CAL37527 AM393766 CAL38641 BC012498 BC049379 AAH49379 BC062426 BC094799 AAH94799 BC118917 BM980302 CR936659 NM_025054 NP_079330 |
Function | Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. {ECO:0000250, ECO:0000269|PubMed:23827681}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}. |
VCPIP1 CRISPR/Cas9 KO Plasmid (h) - sc-409332 from Santa Cruz Biotechnology
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VCPIP1 HDR Plasmid (h) - sc-409332-HDR from Santa Cruz Biotechnology
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VCPIP1 Double Nickase Plasmid (h) - sc-409332-NIC from Santa Cruz Biotechnology
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VCPIP1 Double Nickase Plasmid (h2) - sc-409332-NIC-2 from Santa Cruz Biotechnology
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VCPIP1 CRISPR Activation Plasmid (h) - sc-409332-ACT from Santa Cruz Biotechnology
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VCPIP1 CRISPR Activation Plasmid (h2) - sc-409332-ACT-2 from Santa Cruz Biotechnology
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VCPIP1 Lentiviral Activation Particles (h) - sc-409332-LAC from Santa Cruz Biotechnology
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VCPIP1 Lentiviral Activation Particles (h2) - sc-409332-LAC-2 from Santa Cruz Biotechnology
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VCPIP1 siRNA (h) - sc-77549 from Santa Cruz Biotechnology
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VCPIP1 shRNA Plasmid (h) - sc-77549-SH from Santa Cruz Biotechnology
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VCPIP1 shRNA (h) Lentiviral Particles - sc-77549-V from Santa Cruz Biotechnology
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VCIP135/VCPIP1 RNAi - H00080124-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22657 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22657 from Sigma-Aldrich
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VCPIP1 siRNA (Human) - CRJ2758 from Cohesion Biosciences
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VCPIP1 - MBS8239094 from MyBioSource
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shRNA set against Human VCPIP1 (NM_025054.4) - SHH442468 from Creative biogene
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shRNA set against Human VCPIP1(NM_025054.4) - SHL122304 from Creative biogene
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VCPIP1 shRNA Plasmid (Human) - CHJ2758 from Cohesion Biosciences
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VCPIP1 miRNA 3'UTR clone - MiUTR1H-11106 from Creative biogene
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