Gene Symbol | F2RL2 |
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Entrez Gene | 2151 |
Alt Symbol | PAR-3, PAR3 |
Species | Human |
Gene Type | protein-coding |
Description | coagulation factor II (thrombin) receptor-like 2 |
Other Description | Coagulation factor II receptor-like 2 (protease-actovated receptor 3)|protease-activated receptor 3|proteinase-activated receptor 3|proteinase-activated receptor-3|thrombin receptor-like 2 |
Swissprots | O00254 B2R754 Q7Z3W3 B4DQ13 Q52M68 |
Accessions | AAK51564 EAW95778 O00254 AK298585 BAG60775 AK312848 BAG35701 AL048674 BC093648 AAH93648 BC093650 AAH93650 BC095499 AAH95499 BM989640 BX537386 CAD97628 DC419029 U92971 AAC51218 NM_001256566 NP_001243495 NM_004101 NP_004092 |
Function | Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10079109}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. {ECO:0000269|PubMed:9614115}. |
Top Pathways | Neuroactive ligand-receptor interaction |
PAR-3 CRISPR/Cas9 KO Plasmid (h) - sc-417018 from Santa Cruz Biotechnology
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PAR-3 HDR Plasmid (h) - sc-417018-HDR from Santa Cruz Biotechnology
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PAR-3 Double Nickase Plasmid (h) - sc-417018-NIC from Santa Cruz Biotechnology
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PAR-3 Double Nickase Plasmid (h2) - sc-417018-NIC-2 from Santa Cruz Biotechnology
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PAR-3 CRISPR Activation Plasmid (h) - sc-417018-ACT from Santa Cruz Biotechnology
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PAR-3 CRISPR Activation Plasmid (h2) - sc-417018-ACT-2 from Santa Cruz Biotechnology
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PAR-3 Lentiviral Activation Particles (h) - sc-417018-LAC from Santa Cruz Biotechnology
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PAR-3 Lentiviral Activation Particles (h2) - sc-417018-LAC-2 from Santa Cruz Biotechnology
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PAR-3 siRNA (h) - sc-37143 from Santa Cruz Biotechnology
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PAR-3 shRNA Plasmid (h) - sc-37143-SH from Santa Cruz Biotechnology
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PAR-3 shRNA (h) Lentiviral Particles - sc-37143-V from Santa Cruz Biotechnology
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PAR3/Thrombin Receptor-like 2 RNAi - H00002151-R02 from Novus Biologicals
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MISSION® esiRNA - EHU011191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8069 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8069 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12865 from Sigma-Aldrich
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F2RL2 siRNA (Human) - CRH1495 from Cohesion Biosciences
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F2RL2 - MBS8208555 from MyBioSource
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shRNA set against Human F2RL2 (NM_004101.3) - SHH288465 from Creative biogene
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Human F2RL2 siRNA - orb261997 from Biorbyt
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F2RL2 shRNA Plasmid (Human) - CHH1495 from Cohesion Biosciences
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