| Gene Symbol |
SPHKAP
|
| Entrez Gene |
80309
|
| Alt Symbol |
SKIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SPHK1 interactor, AKAP domain containing
|
| Other Description |
A-kinase anchor protein SPHKAP|SPHK1 (sphingosine kinase type 1) interacting protein|SPHK1-interactor and AKAP domain-containing protein|sphingosine kinase type 1-interacting protein
|
| Swissprots |
Q2M3C7 Q68DA3 Q9C0I5 Q68DR8
|
| Accessions |
Q2M3C7 AB051465 BAB21769 AK090876 BAG52242 AK095042 AK125481 AK127071 BC104954 AAI04955 BC104956 AAI04957 BC143408 CR749297 CAH18152 CR749494 CAH18317 HQ258692 ADR83443 XM_005246867 XP_005246924 XM_005246868 XP_005246925 XM_005246870 XP_005246927 XM_006712777 XP_006712840 XM_006712778 XP_006712841 XM_011511925 XP_011510227 XM_011511926 XP_011510228 XM_011511927 XP_011510229 NM_001142644 NP_001136116 NM_030623 NP_085126
|
| Function |
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm.
|
| Tissue Specificity |
Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}.
|