Gene Symbol | SPHKAP |
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Entrez Gene | 80309 |
Alt Symbol | SKIP |
Species | Human |
Gene Type | protein-coding |
Description | SPHK1 interactor, AKAP domain containing |
Other Description | A-kinase anchor protein SPHKAP|SPHK1 (sphingosine kinase type 1) interacting protein|SPHK1-interactor and AKAP domain-containing protein|sphingosine kinase type 1-interacting protein |
Swissprots | Q2M3C7 Q68DA3 Q9C0I5 Q68DR8 |
Accessions | Q2M3C7 AB051465 BAB21769 AK090876 BAG52242 AK095042 AK125481 AK127071 BC104954 AAI04955 BC104956 AAI04957 BC143408 CR749297 CAH18152 CR749494 CAH18317 HQ258692 ADR83443 XM_005246867 XP_005246924 XM_005246868 XP_005246925 XM_005246870 XP_005246927 XM_006712777 XP_006712840 XM_006712778 XP_006712841 XM_011511925 XP_011510227 XM_011511926 XP_011510228 XM_011511927 XP_011510229 NM_001142644 NP_001136116 NM_030623 NP_085126 |
Function | Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm. |
Tissue Specificity | Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. |
SPHKAP CRISPR/Cas9 KO Plasmid (h) - sc-410155 from Santa Cruz Biotechnology
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SPHKAP HDR Plasmid (h) - sc-410155-HDR from Santa Cruz Biotechnology
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SPHKAP Double Nickase Plasmid (h) - sc-410155-NIC from Santa Cruz Biotechnology
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SPHKAP Double Nickase Plasmid (h2) - sc-410155-NIC-2 from Santa Cruz Biotechnology
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SPHKAP CRISPR Activation Plasmid (h) - sc-410155-ACT from Santa Cruz Biotechnology
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SPHKAP CRISPR Activation Plasmid (h2) - sc-410155-ACT-2 from Santa Cruz Biotechnology
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SPHKAP Lentiviral Activation Particles (h) - sc-410155-LAC from Santa Cruz Biotechnology
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SPHKAP Lentiviral Activation Particles (h2) - sc-410155-LAC-2 from Santa Cruz Biotechnology
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SPHKAP siRNA (h) - sc-94499 from Santa Cruz Biotechnology
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SPHKAP shRNA Plasmid (h) - sc-94499-SH from Santa Cruz Biotechnology
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SPHKAP shRNA (h) Lentiviral Particles - sc-94499-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU063901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20468 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20468 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10333 from Sigma-Aldrich
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SPHKAP siRNA (Human) - CRJ2844 from Cohesion Biosciences
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SPHKAP - MBS8207164 from MyBioSource
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shRNA set against Human SPHKAP (NM_001142644.1) - SHH416628 from Creative biogene
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SPHKAP shRNA Plasmid (Human) - CHJ2844 from Cohesion Biosciences
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SPHKAP miRNA 3'UTR clone - MiUTR3H-12027 from Creative biogene
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SPHKAP miRNA 3'UTR clone - MiUTR3H-12028 from Creative biogene
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