| Gene Symbol |
TRIM58
|
| Entrez Gene |
25893
|
| Alt Symbol |
BIA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 58
|
| Other Description |
E3 ubiquitin-protein ligase TRIM58|tripartite motif-containing 58|tripartite motif-containing protein 58
|
| Swissprots |
Q8NG06 Q6B0H9
|
| Accessions |
Q8NG06 AF327057 AAM63958 AK096188 BC074748 AAH74748 BX537432 CAD97674 BX644877 DN998591 NM_015431 NP_056246
|
| Function |
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. {ECO:0000269|PubMed:25241935}.
|
| Tissue Specificity |
Expressed in erythroblasts. {ECO:0000269|PubMed:25241935}.
|
![Western Blot: TRIM58 Overexpression Lysate (Adult Normal) [NBL1-17308] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRIM58.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7476_TRIM58%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17308-img0002.jpg)