Gene Symbol | TRIM58 |
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Entrez Gene | 25893 |
Alt Symbol | BIA2 |
Species | Human |
Gene Type | protein-coding |
Description | tripartite motif containing 58 |
Other Description | E3 ubiquitin-protein ligase TRIM58|tripartite motif-containing 58|tripartite motif-containing protein 58 |
Swissprots | Q8NG06 Q6B0H9 |
Accessions | Q8NG06 AF327057 AAM63958 AK096188 BC074748 AAH74748 BX537432 CAD97674 BX644877 DN998591 NM_015431 NP_056246 |
Function | E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. {ECO:0000269|PubMed:25241935}. |
Tissue Specificity | Expressed in erythroblasts. {ECO:0000269|PubMed:25241935}. |
TRIM58 CRISPR/Cas9 KO Plasmid (h) - sc-411824 from Santa Cruz Biotechnology
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TRIM58 HDR Plasmid (h) - sc-411824-HDR from Santa Cruz Biotechnology
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TRIM58 Double Nickase Plasmid (h) - sc-411824-NIC from Santa Cruz Biotechnology
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TRIM58 Double Nickase Plasmid (h2) - sc-411824-NIC-2 from Santa Cruz Biotechnology
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TRIM58 CRISPR Activation Plasmid (h) - sc-411824-ACT from Santa Cruz Biotechnology
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TRIM58 CRISPR Activation Plasmid (h2) - sc-411824-ACT-2 from Santa Cruz Biotechnology
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TRIM58 Lentiviral Activation Particles (h) - sc-411824-LAC from Santa Cruz Biotechnology
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TRIM58 Lentiviral Activation Particles (h2) - sc-411824-LAC-2 from Santa Cruz Biotechnology
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TRIM58 siRNA (h) - sc-78989 from Santa Cruz Biotechnology
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TRIM58 shRNA Plasmid (h) - sc-78989-SH from Santa Cruz Biotechnology
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TRIM58 shRNA (h) Lentiviral Particles - sc-78989-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU035051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22000 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22000 from Sigma-Aldrich
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TRIM58 siRNA (Human) - CRH8568 from Cohesion Biosciences
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TRIM58 RNAi - H00025893-R01 from Novus Biologicals
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TRIM58 - MBS828532 from MyBioSource
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shRNA set against Human TRIM58 (NM_015431.3) - SHH434920 from Creative biogene
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shRNA set against Human TRIM58(NM_015431.3) - SHL044062 from Creative biogene
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TRIM58 shRNA Plasmid (Human) - CHH8568 from Cohesion Biosciences
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TRIM58 miRNA 3'UTR clone - MiUTR1H-10750 from Creative biogene
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