ATP8A1

Gene Symbol	ATP8A1
Entrez Gene	10396
Alt Symbol	ATPASEII, ATPIA, ATPP2
Species	Human
Gene Type	protein-coding
Description	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Other Description	ATPase II|ATPase class I type 8A member 1|P4-ATPase flippase complex alpha subunit ATP8A1|aminophospholipid translocase|chromaffin granule ATPase II|phospholipid-transporting ATPase IA|probable phospholipid-transporting ATPase IA
Swissprots	Q4W5J7 Q32M35 Q4W5P2 Q32M36 Q9Y2Q0
Accessions	AAV54111 AAV54112 AAY40924 AAY40980 EAW93003 EAW93004 Q9Y2Q0 AB013452 BAA77248 AB209687 BAD92924 AF035315 AF067820 AAD34706 AK027252 BC020943 AAH20943 BC109317 AAI09318 BC109318 AAI09319 BP232466 BX648675 XM_005248043 XP_005248100 XM_011513615 XP_011511917 XM_011513616 XP_011511918 XM_011513618 XP_011511920 XM_011513619 XP_011511921 XR_925117 XR_925118 NM_001105529 NP_001098999 NM_006095 NP_006086
Function	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane. Localizes to plasma membranes of red blood cells (By similarity). {ECO:0000250}.
Tissue Specificity	Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ATP8A1 (S-17) - sc-249991 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ATP8A1 (W-16) - sc-249992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

pan ATP (H-39) - sc-99109 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-ATP8A1 antibody - ab130434 from Abcam Host Rabbit Clonality Polyclonal

Anti-ATP8A1 Antibody - LS-C335333 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ATP8A1 Antibody - NBP2-30403 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ATP8A1 Antibody - NBP2-30711 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ATP8A1 antibody produced in rabbit - HPA052935 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ATP8A1 antibody produced in rabbit - HPA049948 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit anti-human ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 (OACA02414) - OACA02414 from Aviva Systems Biology Prices $425.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

ATP8A1 Polyclonal Antibody - A3369 from ABclonal Prices $130.00, $220.00, $380.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

ATP8A1 antibody - 70R-15927 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

ATP8A1 Antibody - abx002408 from Abbexa Host Rabbit Clonality Polyclonal

ATP8A1 Antibody - abx111134 from Abbexa Host Rabbit Clonality Polyclonal

ATP8A1 antibody - 21565-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

Anti-ATP8A1, Polyclonal Antibody - 25-A3369 from ARP American Research Products Prices $299.00, $449.00 Sizes 100 µg, 200 µg Host Rabbit Clonality Polyclonal

ATP8A1 antibody - 21565-1-AP from Proteintech Group Prices $279.00 Sizes con: 24 μg/150μl Host Rabbit Clonality Polyclonal

Anti-ATP8A1 antibody - STJ22733 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal

ATP8A1 - A3369 from NeoScientific Prices $480.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

ATP8A1, Polyclonal Antibody - MBS2517074 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

ATP8A1 , Polyclonal Antibody - MBS128907 from MyBioSource Prices $230.00, $305.00, $460.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 , Polyclonal Antibody - MBS714745 from MyBioSource Prices $230.00, $500.00 Sizes 50 µl, 150 µl Host Rabbit Clonality Polyclonal

ATP8A1 Antibody - EPP10716 from Elabscience Prices $296.00, $485.00 Sizes 120 μl, 200 μl Host Rabbit Clonality Polyclonal

Anti-ATP8A1 (aa 1-69) polyclonal antibody - DPABH-14743 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Rabbit Anti-Human ATP8A1 Polyclonal antibody - DPABH-24510 from Creative Diagnostics Host Rabbit Clonality Polyclonal

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