| Gene Symbol |
ATP8A1
|
| Entrez Gene |
10396
|
| Alt Symbol |
ATPASEII, ATPIA, ATPP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
|
| Other Description |
ATPase II|ATPase class I type 8A member 1|P4-ATPase flippase complex alpha subunit ATP8A1|aminophospholipid translocase|chromaffin granule ATPase II|phospholipid-transporting ATPase IA|probable phospholipid-transporting ATPase IA
|
| Swissprots |
Q4W5J7 Q32M35 Q4W5P2 Q32M36 Q9Y2Q0
|
| Accessions |
AAV54111 AAV54112 AAY40924 AAY40980 EAW93003 EAW93004 Q9Y2Q0 AB013452 BAA77248 AB209687 BAD92924 AF035315 AF067820 AAD34706 AK027252 BC020943 AAH20943 BC109317 AAI09318 BC109318 AAI09319 BP232466 BX648675 XM_005248043 XP_005248100 XM_011513615 XP_011511917 XM_011513616 XP_011511918 XM_011513618 XP_011511920 XM_011513619 XP_011511921 XR_925117 XR_925118 NM_001105529 NP_001098999 NM_006095 NP_006086
|
| Function |
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane. Localizes to plasma membranes of red blood cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle.
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