ATP8A1

Gene Symbol	ATP8A1
Entrez Gene	10396
Alt Symbol	ATPASEII, ATPIA, ATPP2
Species	Human
Gene Type	protein-coding
Description	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Other Description	ATPase II|ATPase class I type 8A member 1|P4-ATPase flippase complex alpha subunit ATP8A1|aminophospholipid translocase|chromaffin granule ATPase II|phospholipid-transporting ATPase IA|probable phospholipid-transporting ATPase IA
Swissprots	Q4W5J7 Q32M35 Q4W5P2 Q32M36 Q9Y2Q0
Accessions	AAV54111 AAV54112 AAY40924 AAY40980 EAW93003 EAW93004 Q9Y2Q0 AB013452 BAA77248 AB209687 BAD92924 AF035315 AF067820 AAD34706 AK027252 BC020943 AAH20943 BC109317 AAI09318 BC109318 AAI09319 BP232466 BX648675 XM_005248043 XP_005248100 XM_011513615 XP_011511917 XM_011513616 XP_011511918 XM_011513618 XP_011511920 XM_011513619 XP_011511921 XR_925117 XR_925118 NM_001105529 NP_001098999 NM_006095 NP_006086
Function	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane. Localizes to plasma membranes of red blood cells (By similarity). {ECO:0000250}.
Tissue Specificity	Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ATP8A1 CRISPR/Cas9 KO Plasmid (h) - sc-406843 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 HDR Plasmid (h) - sc-406843-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 Double Nickase Plasmid (h) - sc-406843-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 Double Nickase Plasmid (h2) - sc-406843-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 CRISPR Activation Plasmid (h) - sc-406843-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 CRISPR Activation Plasmid (h2) - sc-406843-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 Lentiviral Activation Particles (h) - sc-406843-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 Lentiviral Activation Particles (h2) - sc-406843-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 siRNA (h) - sc-89020 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATP8A1 shRNA Plasmid (h) - sc-89020-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATP8A1 shRNA (h) Lentiviral Particles - sc-89020-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATP8A1 RNAi - H00010396-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU069321 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3741 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3741 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01854 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01854

ATP8A1 siRNA (Human) - CRH7045 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATP8A1 - MBS8227409 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATP8A1 CRISPR/Cas9 KO Plasmid (h2) - sc-406843-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A1 HDR Plasmid (h2) - sc-406843-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human ATP8A1 (NM_006095.2) - SHH243274 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ATP8A1(NM_006095.2) - SHG084601 from Creative biogene Category siRNA Species Reactivities Human

Human ATP8A1 siRNA - orb267547 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATP8A1 shRNA Plasmid (Human) - CHH7045 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATP8A1 miRNA 3'UTR clone - MiUTR1H-00727 from Creative biogene Species Reactivities Human

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