| Gene Symbol |
PLVAP
|
| Entrez Gene |
83483
|
| Alt Symbol |
FELS, PV-1, PV1, gp68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plasmalemma vesicle associated protein
|
| Other Description |
fenestrated endothelial-linked structure protein|fenestrated-endothelial linked structure protein; PV-1 protein|plasmalemma vesicle protein 1|plasmalemma vesicle-associated protein
|
| Swissprots |
Q8ND68 Q86VP0 Q9BX97 Q8N8Y0 Q8TER8 Q9BZD5
|
| Accessions |
EAW84600 Q9BX97 AF326591 AAK11226 AF348827 AAK20040 AK074054 BAB84880 AK096030 BAC04681 AK313837 AL834363 CAD39027 AW874637 BC050365 AAH50365 BC056414 AAH56414 BX380375 D83199 HQ447733 ADQ32218 NM_031310 NP_112600
|
| Function |
Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. {ECO:0000269|PubMed:15155804}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Membrane- associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium. {ECO:0000269|PubMed:11401446, ECO:0000269|PubMed:15971170}.
|
![Western Blot: PLVAP Overexpression Lysate (Adult Normal) [NBP2-06137] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PLVAP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10628_PLVAP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06137-img0001.jpg)