Gene Symbol | PLVAP |
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Entrez Gene | 83483 |
Alt Symbol | FELS, PV-1, PV1, gp68 |
Species | Human |
Gene Type | protein-coding |
Description | plasmalemma vesicle associated protein |
Other Description | fenestrated endothelial-linked structure protein|fenestrated-endothelial linked structure protein; PV-1 protein|plasmalemma vesicle protein 1|plasmalemma vesicle-associated protein |
Swissprots | Q8ND68 Q86VP0 Q9BX97 Q8N8Y0 Q8TER8 Q9BZD5 |
Accessions | EAW84600 Q9BX97 AF326591 AAK11226 AF348827 AAK20040 AK074054 BAB84880 AK096030 BAC04681 AK313837 AL834363 CAD39027 AW874637 BC050365 AAH50365 BC056414 AAH56414 BX380375 D83199 HQ447733 ADQ32218 NM_031310 NP_112600 |
Function | Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. {ECO:0000269|PubMed:15155804}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Membrane- associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium. {ECO:0000269|PubMed:11401446, ECO:0000269|PubMed:15971170}. |
PV1 CRISPR/Cas9 KO Plasmid (h) - sc-403746 from Santa Cruz Biotechnology
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PV1 HDR Plasmid (h) - sc-403746-HDR from Santa Cruz Biotechnology
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PV1 Double Nickase Plasmid (h) - sc-403746-NIC from Santa Cruz Biotechnology
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PV1 Double Nickase Plasmid (h2) - sc-403746-NIC-2 from Santa Cruz Biotechnology
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PV1 CRISPR Activation Plasmid (h) - sc-403746-ACT from Santa Cruz Biotechnology
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PV1 CRISPR Activation Plasmid (h2) - sc-403746-ACT-2 from Santa Cruz Biotechnology
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PV1 Lentiviral Activation Particles (h) - sc-403746-LAC from Santa Cruz Biotechnology
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PV1 Lentiviral Activation Particles (h2) - sc-403746-LAC-2 from Santa Cruz Biotechnology
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PV1 siRNA (h) - sc-61421 from Santa Cruz Biotechnology
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PV1 shRNA Plasmid (h) - sc-61421-SH from Santa Cruz Biotechnology
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PV1 shRNA (h) Lentiviral Particles - sc-61421-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17006 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17006 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07011 from Sigma-Aldrich
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PLVAP siRNA (Human) - CRJ3118 from Cohesion Biosciences
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PLVAP RNAi - H00083483-R01 from Novus Biologicals
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shRNA set against Human PLVAP (NM_031310.1) - SHH378156 from Creative biogene
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shRNA set against Human PLVAP(NM_031310.1) - SHR105180 from Creative biogene
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PLVAP shRNA Plasmid (Human) - CHJ3118 from Cohesion Biosciences
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PLVAP miRNA 3'UTR clone - MiUTR1H-08017 from Creative biogene
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