FOXA2

Gene Symbol FOXA2
Entrez Gene 3170
Alt Symbol HNF3B, TCF3B
Species Human
Gene Type protein-coding
Description forkhead box A2
Other Description HNF-3-beta|HNF-3B|TCF-3B|forkhead box protein A2|hepatic nuclear factor-3-beta|hepatocyte nuclear factor 3, beta|hepatocyte nuclear factor 3-beta|transcription factor 3B
Swissprots Q8WUW4 Q96DF7 Q9Y261
Accessions AAD41081 AAD51978 ACA06111 CAJ01277 CAJ01278 EAX10174 EAX10175 Q9Y261 AA469087 AB028021 BAA78106 AI268650 AI302734 AK301611 BAG63097 BC006545 AAH06545 BC011780 AAH11780 BC019288 AAH19288 BM273279 BQ643619 DQ892883 ABM83809 DQ896132 ABM87131 XM_006723562 XP_006723625 XM_011529231 XP_011527533 NM_021784 NP_068556 NM_153675 NP_710141
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes im
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm {ECO:0000269|PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Top Pathways Maturity onset diabetes of the young

Mouse FOXA2 ELISA Kit (Sandwich ELISA) - LS-F6501 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.126 ng/ml
Range 0.313-20 ng/ml

FOXA2 (Human) IP-WB Antibody Pair - H00003170-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

FOXA2 (Human) IP-WB Antibody Pair - H00003170-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

forkhead box A2, ELISA Kit - MBS9339371 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.625ng/ml-20ng/ml.

ELISA Kit for Forkhead Box Protein A2 (FOXA2) - SEG208Mu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.126ng/mL..
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human FOXA2 ELISA Kit - E015352 from Biobool

Category ELISA Kit
Sensitivity 0.1ng/ml.

anti-FOXA2 / HNF3B antibody - ARG63339 from Arigo Biolaboratories

Category ELISA Kit
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