FOXA2

Gene Symbol	FOXA2
Entrez Gene	3170
Alt Symbol	HNF3B, TCF3B
Species	Human
Gene Type	protein-coding
Description	forkhead box A2
Other Description	HNF-3-beta|HNF-3B|TCF-3B|forkhead box protein A2|hepatic nuclear factor-3-beta|hepatocyte nuclear factor 3, beta|hepatocyte nuclear factor 3-beta|transcription factor 3B
Swissprots	Q8WUW4 Q96DF7 Q9Y261
Accessions	AAD41081 AAD51978 ACA06111 CAJ01277 CAJ01278 EAX10174 EAX10175 Q9Y261 AA469087 AB028021 BAA78106 AI268650 AI302734 AK301611 BAG63097 BC006545 AAH06545 BC011780 AAH11780 BC019288 AAH19288 BM273279 BQ643619 DQ892883 ABM83809 DQ896132 ABM87131 XM_006723562 XP_006723625 XM_011529231 XP_011527533 NM_021784 NP_068556 NM_153675 NP_710141
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes im
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm {ECO:0000269|PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Top Pathways	Maturity onset diabetes of the young

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FOXA2 peptide - ab176237 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human FOXA2 full length protein - ab95848 from Abcam Category Protein Source E. coli Species Human

Human FOXA2 peptide - ab25739 from Abcam Category Peptide

Human FOXA2 peptide - ab23065 from Abcam Category Peptide Species Human

FOXA2 Antibody Blocking Peptide - LS-E766 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E2272 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E25559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E14290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E14291 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E31409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FOXA2 Antibody Blocking Peptide - LS-E11149 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E13296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA2 Antibody Blocking Peptide - LS-E13295 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HNF-3 beta/FoxA2 Protein - H00003170-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HNF-3 beta/FoxA2 Protein - H00003170-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

FOXA2-Antibody-Center-Blocking-peptide - BP11120c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXA2-Antibody-C-term-Blocking-peptide - BP12031b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXA2-Antibody-Center-T156-Blocking-Peptide - BP13206c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXA2 blocking peptide - GTX25074-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

FOXA2 Peptide - AC21-0388-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FOXA2 / HNF3B - H00003170-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

FOXA2 / HNF3B - H00003170-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FOXA2 / HNF3B - H00003170-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FOXA2 Peptide - 45-600P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

FOXA2 Peptide - 7257P from ProSci Category Peptide Species Human

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