FOXA2

Gene Symbol	FOXA2
Entrez Gene	3170
Alt Symbol	HNF3B, TCF3B
Species	Human
Gene Type	protein-coding
Description	forkhead box A2
Other Description	HNF-3-beta|HNF-3B|TCF-3B|forkhead box protein A2|hepatic nuclear factor-3-beta|hepatocyte nuclear factor 3, beta|hepatocyte nuclear factor 3-beta|transcription factor 3B
Swissprots	Q8WUW4 Q96DF7 Q9Y261
Accessions	AAD41081 AAD51978 ACA06111 CAJ01277 CAJ01278 EAX10174 EAX10175 Q9Y261 AA469087 AB028021 BAA78106 AI268650 AI302734 AK301611 BAG63097 BC006545 AAH06545 BC011780 AAH11780 BC019288 AAH19288 BM273279 BQ643619 DQ892883 ABM83809 DQ896132 ABM87131 XM_006723562 XP_006723625 XM_011529231 XP_011527533 NM_021784 NP_068556 NM_153675 NP_710141
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes im
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm {ECO:0000269|PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Top Pathways	Maturity onset diabetes of the young

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HNF-3β siRNA (h) - sc-35569 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HNF-3β shRNA Plasmid (h) - sc-35569-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HNF-3β shRNA (h) Lentiviral Particles - sc-35569-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HNF-3 beta/FoxA2 RNAi - H00003170-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HNF-3 beta/FoxA2 RNAi - H00003170-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HNF-3 beta/FoxA2 RNAi - H00003170-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8875 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8875 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05684 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05684

FOXA2 siRNA (Human) - CRH2164 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FOXA2 - MBS8225927 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FOXA2 (NM_021784.4) - SHH296373 from Creative biogene Category siRNA Species Reactivities Human

Human FOXA2 siRNA - orb262666 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FOXA2 shRNA Plasmid (Human) - CHH2164 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FOXA2 miRNA 3'UTR clone - MiUTR3H-03247 from Creative biogene Species Reactivities Human

FOXA2 miRNA 3'UTR clone - MiUTR3H-03248 from Creative biogene Species Reactivities Human

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