| Gene Symbol |
FKBP1B
|
| Entrez Gene |
2281
|
| Alt Symbol |
FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FK506 binding protein 1B, 12.6 kDa
|
| Other Description |
12.6 kDa FK506-binding protein|12.6 kDa FKBP|FK506-binding protein 12.6|FK506-binding protein 1B|FKBP-12.6|FKBP-1B|PPIase FKBP1B|calstabin 2|h-FKBP-12|immunophilin FKBP12.6|peptidyl-prolyl cis-trans isomerase FKBP1B|rotamase
|
| Swissprots |
Q9BQ40 P68106 Q53TM2 Q16645 Q13664
|
| Accessions |
AAY14663 BAE44300 CBF58189 CBU83624 EAX00768 EAX00769 EAX00770 P68106 AF322070 AAK11191 BC002614 AAH02614 BC050998 BF969580 D38037 BAA07232 L37086 AAC37581 S69800 AAB30685 S69815 AAB30684 XM_011532699 XP_011531001 NM_004116 NP_004107 NM_054033 NP_473374
|
| Function |
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.
|
| Tissue Specificity |
Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269|PubMed:10830164}.
|
![Western Blot: FKBP1B Overexpression Lysate (Adult Normal) [NBL1-10734] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FKBP1B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3731_FKBP1B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10734-img0002.jpg)