Gene Symbol | FKBP1B |
---|---|
Entrez Gene | 2281 |
Alt Symbol | FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase |
Species | Human |
Gene Type | protein-coding |
Description | FK506 binding protein 1B, 12.6 kDa |
Other Description | 12.6 kDa FK506-binding protein|12.6 kDa FKBP|FK506-binding protein 12.6|FK506-binding protein 1B|FKBP-12.6|FKBP-1B|PPIase FKBP1B|calstabin 2|h-FKBP-12|immunophilin FKBP12.6|peptidyl-prolyl cis-trans isomerase FKBP1B|rotamase |
Swissprots | Q9BQ40 P68106 Q53TM2 Q16645 Q13664 |
Accessions | AAY14663 BAE44300 CBF58189 CBU83624 EAX00768 EAX00769 EAX00770 P68106 AF322070 AAK11191 BC002614 AAH02614 BC050998 BF969580 D38037 BAA07232 L37086 AAC37581 S69800 AAB30685 S69815 AAB30684 XM_011532699 XP_011531001 NM_004116 NP_004107 NM_054033 NP_473374 |
Function | Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
Subcellular Location | Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. |
Tissue Specificity | Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269|PubMed:10830164}. |