Gene Symbol | APOA1 |
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Entrez Gene | 335 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein A-I |
Other Description | apo-AI |
Swissprots | Q9UCT8 A8K866 P02647 Q9UCS8 Q6Q785 Q6LDN9 |
Accessions | AAA51746 AAB59514 AAD34604 AAL92035 AAQ91811 AAS68227 ACA05932 ACA05933 ACA05934 ACA05935 ACA05936 AFU51373 CAA25519 CAA30377 EAW67274 EAW67275 EAW67276 EAW67277 P02647 A14829 CAA01198 A15879 CAA01253 AK292231 BAF84920 BC005380 AAH05380 BC110286 AAI10287 DQ893073 ABM83999 DQ896330 ABM87329 M11791 AAA35545 M27875 AAA62829 M29068 AAA51747 X00566 CAA25232 X02162 CAA26097 XM_005271539 XP_005271596 XM_005271540 XP_005271597 NM_000039 NP_000030 |
Function | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
Subcellular Location | Secreted. |
Tissue Specificity | Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. {ECO:0000269|PubMed:12576517}. |
Top Pathways | PPAR signaling pathway, African trypanosomiasis, Fat digestion and absorption, Vitamin digestion and absorption |
Apolipoprotein AI (APOA1) Human ELISA Kit - ab108804 from Abcam
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Apolipoprotein AI (APOA1) Human ELISA Kit - ab108803 from Abcam
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Apolipoprotein AI (APOA1) Human SimpleStep ELISA™ Kit - ab189576 from Abcam
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HDL Human ELISA Kit - ab125961 from Abcam
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Rat APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F4180 from LifeSpan Bioscience
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Mouse APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F5982 from LifeSpan Bioscience
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Human APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F4649 from LifeSpan Bioscience
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Rabbit APOA1 / Apolipoprotein A 1 ELISA Kit (Competitive EIA) - LS-F4736 from LifeSpan Bioscience
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Pig APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F6188 from LifeSpan Bioscience
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Dog APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F9738 from LifeSpan Bioscience
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Rhesus monkey APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F9676 from LifeSpan Bioscience
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Human APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F10071 from LifeSpan Bioscience
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Mouse APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F10857 from LifeSpan Bioscience
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Rat APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F10856 from LifeSpan Bioscience
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Human APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F10855 from LifeSpan Bioscience
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Rabbit APOA1 / Apolipoprotein A 1 ELISA Kit - LS-F10858 from LifeSpan Bioscience
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Human APOA1 / Apolipoprotein A-I ELISA Kit - RAB0607 from Sigma-Aldrich
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Apolipoprotein A1, ApoA1, Human, ELISA Kit - E-EL-H0125 from ARP American Research Products
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Apolipoprotein A-I, APOA1, Human, ELISA Kit - E0604h from ARP American Research Products
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Apolipoprotein A1 (Apo-A1), Human, ELISA Kit - CSB-E08103h from ARP American Research Products
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Apolipoprotein A1 (APOA1), Human, ELISA Kit - SEA519Hu from ARP American Research Products
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Apolipoprotein A1, ApoA1, Rat, ELISA Kit - E-EL-R1210 from ARP American Research Products
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Apolipoprotein A1, ApoA1, Rabbit, ELISA Kit - E-EL-RB1555 from ARP American Research Products
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Apolipoprotein A1, ApoA1, Chicken, ELISA Kit - E-EL-Ch0118 from ARP American Research Products
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Apolipoprotein A1, ApoA1, Porcine, ELISA Kit - E-EL-P0987 from ARP American Research Products
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