| Gene Symbol | APOA1 |
|---|---|
| Entrez Gene | 335 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | apolipoprotein A-I |
| Other Description | apo-AI |
| Swissprots | Q9UCT8 A8K866 P02647 Q9UCS8 Q6Q785 Q6LDN9 |
| Accessions | AAA51746 AAB59514 AAD34604 AAL92035 AAQ91811 AAS68227 ACA05932 ACA05933 ACA05934 ACA05935 ACA05936 AFU51373 CAA25519 CAA30377 EAW67274 EAW67275 EAW67276 EAW67277 P02647 A14829 CAA01198 A15879 CAA01253 AK292231 BAF84920 BC005380 AAH05380 BC110286 AAI10287 DQ893073 ABM83999 DQ896330 ABM87329 M11791 AAA35545 M27875 AAA62829 M29068 AAA51747 X00566 CAA25232 X02162 CAA26097 XM_005271539 XP_005271596 XM_005271540 XP_005271597 NM_000039 NP_000030 |
| Function | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. {ECO:0000269|PubMed:12576517}. |
| Top Pathways | PPAR signaling pathway, African trypanosomiasis, Fat digestion and absorption, Vitamin digestion and absorption |
apoA-I CRISPR/Cas9 KO Plasmid (h) - sc-400499 from Santa Cruz Biotechnology
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apoA-I HDR Plasmid (h) - sc-400499-HDR from Santa Cruz Biotechnology
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apoA-I Double Nickase Plasmid (h) - sc-400499-NIC from Santa Cruz Biotechnology
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apoA-I Double Nickase Plasmid (h2) - sc-400499-NIC-2 from Santa Cruz Biotechnology
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apoA-I CRISPR Activation Plasmid (h) - sc-400499-ACT from Santa Cruz Biotechnology
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apoA-I CRISPR Activation Plasmid (h2) - sc-400499-ACT-2 from Santa Cruz Biotechnology
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apoA-I Lentiviral Activation Particles (h) - sc-400499-LAC from Santa Cruz Biotechnology
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apoA-I Lentiviral Activation Particles (h2) - sc-400499-LAC-2 from Santa Cruz Biotechnology
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apoA-I siRNA (h) - sc-41177 from Santa Cruz Biotechnology
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apoA-I shRNA Plasmid (h) - sc-41177-SH from Santa Cruz Biotechnology
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apoA-I shRNA (h) Lentiviral Particles - sc-41177-V from Santa Cruz Biotechnology
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Apolipoprotein A-I/ApoA1 RNAi - H00000335-R01 from Novus Biologicals
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MISSION® esiRNA - EHU127471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1604 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1604 from Sigma-Aldrich
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APOA1 siRNA (Human) - CRH0236 from Cohesion Biosciences
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APOA1 - MBS8230294 from MyBioSource
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shRNA set against Human APOA1 (NM_000039.1) - SHH238318 from Creative biogene
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shRNA set against Human APOA1(NM_000039.1) - SHG064891 from Creative biogene
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APOA1 shRNA Plasmid (Human) - CHH0236 from Cohesion Biosciences
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APOA1 miRNA 3'UTR clone - MiUTR1H-00468 from Creative biogene
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