| Gene Symbol |
LPAR4
|
| Entrez Gene |
2846
|
| Alt Symbol |
GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidic acid receptor 4
|
| Other Description |
G protein-coupled receptor 23|G-protein coupled receptor 23|LPA receptor 4|LPA-4|P2Y purinoceptor 9|P2Y5-like receptor|purinergic receptor 9
|
| Swissprots |
Q502U9 Q6NSP5 O15132 B2RAC7 Q99677
|
| Accessions |
AAB62087 AAB66322 AAC51301 AAP58404 EAW98596 Q99677 AA424772 AK314134 BAG36824 AU129897 BC069996 AAH69996 BC074722 AAH74722 BC095538 AAH95538 BM973092 BX100826 DA368656 DA735126 U90322 AAB62088 XM_005262126 XP_005262183 XM_006724639 XP_006724702 XM_011530921 XP_011529223 NM_001278000 NP_001264929 NM_005296 NP_005287
|
| Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA. {ECO:0000269|PubMed:12724320}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus. {ECO:0000269|PubMed:12724320}.
|
| Top Pathways |
PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction
|