Gene Symbol | LPAR4 |
---|---|
Entrez Gene | 2846 |
Alt Symbol | GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9 |
Species | Human |
Gene Type | protein-coding |
Description | lysophosphatidic acid receptor 4 |
Other Description | G protein-coupled receptor 23|G-protein coupled receptor 23|LPA receptor 4|LPA-4|P2Y purinoceptor 9|P2Y5-like receptor|purinergic receptor 9 |
Swissprots | Q502U9 Q6NSP5 O15132 B2RAC7 Q99677 |
Accessions | AAB62087 AAB66322 AAC51301 AAP58404 EAW98596 Q99677 AA424772 AK314134 BAG36824 AU129897 BC069996 AAH69996 BC074722 AAH74722 BC095538 AAH95538 BM973092 BX100826 DA368656 DA735126 U90322 AAB62088 XM_005262126 XP_005262183 XM_006724639 XP_006724702 XM_011530921 XP_011529223 NM_001278000 NP_001264929 NM_005296 NP_005287 |
Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA. {ECO:0000269|PubMed:12724320}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus. {ECO:0000269|PubMed:12724320}. |
Top Pathways | PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction |
P2Y9 CRISPR/Cas9 KO Plasmid (h) - sc-404862 from Santa Cruz Biotechnology
|
||||||||
P2Y9 HDR Plasmid (h) - sc-404862-HDR from Santa Cruz Biotechnology
|
||||||||
P2Y9 Double Nickase Plasmid (h) - sc-404862-NIC from Santa Cruz Biotechnology
|
||||||||
P2Y9 Double Nickase Plasmid (h2) - sc-404862-NIC-2 from Santa Cruz Biotechnology
|
||||||||
P2Y9 CRISPR Activation Plasmid (h) - sc-404862-ACT from Santa Cruz Biotechnology
|
||||||||
P2Y9 CRISPR Activation Plasmid (h2) - sc-404862-ACT-2 from Santa Cruz Biotechnology
|
||||||||
P2Y9 Lentiviral Activation Particles (h) - sc-404862-LAC from Santa Cruz Biotechnology
|
||||||||
P2Y9 Lentiviral Activation Particles (h2) - sc-404862-LAC-2 from Santa Cruz Biotechnology
|
||||||||
P2Y9 siRNA (h) - sc-45614 from Santa Cruz Biotechnology
|
||||||||
P2Y9 shRNA Plasmid (h) - sc-45614-SH from Santa Cruz Biotechnology
|
||||||||
P2Y9 shRNA (h) Lentiviral Particles - sc-45614-V from Santa Cruz Biotechnology
|
||||||||
P2Y9 RNAi - H00002846-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU039111 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12644 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12644 from Sigma-Aldrich
|
||||||||
LPAR4 siRNA (Human) - CRH1909 from Cohesion Biosciences
|
||||||||
LPAR4 shRNA Plasmid (Human) - CHH1909 from Cohesion Biosciences
|