| Gene Symbol |
Cebpb
|
| Entrez Gene |
24253
|
| Alt Symbol |
Il6dbp, NF-IL6, TCF5
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
CCAAT/enhancer binding protein (C/EBP), beta
|
| Other Description |
C/EBP beta|CCAAT/enhancer-binding protein beta|IL-6DBP|SF-B|interleukin-6-dependent-binding protein|nuclear factor-IL6|silencer factor B
|
| Swissprots |
P21272 A2VD03
|
| Accessions |
AAA40972 CAA38443 P21272 BC129071 AAI29072 M57235 AAA19669 S77528 AAB21102 X60769 CAA43179 NM_001301715 NP_001288644 NM_001301720 NP_001288649 NM_024125 NP_077039
|
| Function |
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. {ECO:0000269|PubMed:1934061}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Liver and lung.
|
| Top Pathways |
Tuberculosis, TNF signaling pathway, Transcriptional misregulation in cancer
|