| Gene Symbol |
USP15
|
| Entrez Gene |
9958
|
| Alt Symbol |
UNPH-2, UNPH4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 15
|
| Other Description |
deubiquitinating enzyme 15|ubiquitin carboxyl-terminal hydrolase 15|ubiquitin thioesterase 15|ubiquitin thiolesterase 15|ubiquitin-specific-processing protease 15
|
| Swissprots |
Q9HCA6 Q08AL5 Q9Y4E8 Q9H8G9 Q9Y5B5 Q9UNP0
|
| Accessions |
EAW97104 EAW97105 EAW97106 Q9Y4E8 AB011101 BAA25455 AF013990 AAG28973 AF106069 AAD52099 AF153604 AAD41086 AI027693 AK023703 BAB14648 AK292337 BAF85026 AK295947 BAH12226 AK297759 BAG60108 BC020688 AAH20688 BC063454 AAH63454 BC110908 AAI10909 BC125123 AAI25124 DB451322 XM_005269259 XP_005269316 XM_005269261 XP_005269318 XM_006719718 XP_006719781 XR_944851 NM_001252078 NP_001239007 NM_001252079 NP_001239008 NM_006313 NP_006304
|
| Function |
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated compone
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Nucleus {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}.
|
| Tissue Specificity |
Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
|