USP15

Gene Symbol USP15
Entrez Gene 9958
Alt Symbol UNPH-2, UNPH4
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 15
Other Description deubiquitinating enzyme 15|ubiquitin carboxyl-terminal hydrolase 15|ubiquitin thioesterase 15|ubiquitin thiolesterase 15|ubiquitin-specific-processing protease 15
Swissprots Q9HCA6 Q08AL5 Q9Y4E8 Q9H8G9 Q9Y5B5 Q9UNP0
Accessions EAW97104 EAW97105 EAW97106 Q9Y4E8 AB011101 BAA25455 AF013990 AAG28973 AF106069 AAD52099 AF153604 AAD41086 AI027693 AK023703 BAB14648 AK292337 BAF85026 AK295947 BAH12226 AK297759 BAG60108 BC020688 AAH20688 BC063454 AAH63454 BC110908 AAI10909 BC125123 AAI25124 DB451322 XM_005269259 XP_005269316 XM_005269261 XP_005269318 XM_006719718 XP_006719781 XR_944851 NM_001252078 NP_001239007 NM_001252079 NP_001239008 NM_006313 NP_006304
Function Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated compone
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Nucleus {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}.
Tissue Specificity Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

USP15 (S-20) - sc-69081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
USP15 (S-20): sc-69081. Western blot analysis of USP15 expression in rat heart (A), mouse brain (B), mouse cerebellum (C) and mouse skeletal muscle (D) tissue extracts.

USP15 (2D5) - sc-100629 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
USP15 (2D5): sc-100629. Western blot analysis of USP15 expression in Hep G2 whole cell lysate.

Anti-USP15 antibody - ab56900 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HeLa cells stained with ab56900 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab56900, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-USP15 antibody - ab97533 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraformaldehyde-fixed A431, using USP15(GTX104644) antibody at 1:200 dilution.

Anti-USP15 antibody - ab118266 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-USP15 antibody (ab118266) at 1/1000 dilution + K562 cell lysate

Anti-USP15 antibody - Carboxyterminal end - ab71242 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-USP15 antibody - Carboxyterminal end (ab71242) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysatesLane 2 : USP15 transfected 293 cell lysatesLysates/proteins at 2 µg per lane.

Anti-USP15 antibody - N-terminal - ab138322 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-USP15 antibody - N-terminal (ab138322) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-USP15 Antibody (aa625-675) - LS-C91867 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa254-282, AP) - LS-C273169 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa254-282, APC) - LS-C273170 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa68-117) - LS-C200807 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using USP15 antibody.

Anti-USP15 Antibody (aa254-282, Biotin) - LS-C273171 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa254-282, FITC) - LS-C273172 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa254-282, Azide-free, HRP) - LS-C273173 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa254-282, PE) - LS-C273175 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (N-Terminus, AP) - LS-C284177 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (N-Terminus, APC) - LS-C284178 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa691-740) - LS-C116948 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
USP15 antibody LS-C116948 Western blot of Jurkat lysate.

Anti-USP15 Antibody (N-Terminus, FITC) - LS-C284180 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (N-Terminus, PE) - LS-C284181 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (N-Terminus, Biotin) - LS-C284179 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa151-180) - LS-C99556 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-USP15 antibody is used in Western blot to detect USP15 in mouse brain tissue lysate.

Anti-USP15 Antibody (N-Terminus, Azide-free, HRP) - LS-C284182 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody (aa253-282) - LS-C326227 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP15 Antibody - LS-C305921 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
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