USP15

Gene Symbol	USP15
Entrez Gene	9958
Alt Symbol	UNPH-2, UNPH4
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 15
Other Description	deubiquitinating enzyme 15|ubiquitin carboxyl-terminal hydrolase 15|ubiquitin thioesterase 15|ubiquitin thiolesterase 15|ubiquitin-specific-processing protease 15
Swissprots	Q9HCA6 Q08AL5 Q9Y4E8 Q9H8G9 Q9Y5B5 Q9UNP0
Accessions	EAW97104 EAW97105 EAW97106 Q9Y4E8 AB011101 BAA25455 AF013990 AAG28973 AF106069 AAD52099 AF153604 AAD41086 AI027693 AK023703 BAB14648 AK292337 BAF85026 AK295947 BAH12226 AK297759 BAG60108 BC020688 AAH20688 BC063454 AAH63454 BC110908 AAI10909 BC125123 AAI25124 DB451322 XM_005269259 XP_005269316 XM_005269261 XP_005269318 XM_006719718 XP_006719781 XR_944851 NM_001252078 NP_001239007 NM_001252079 NP_001239008 NM_006313 NP_006304
Function	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated compone
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Nucleus {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}.
Tissue Specificity	Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human USP15 full length protein - ab131965 from Abcam Category Protein Source Wheat germ Species Human

Human USP15 full length protein - ab167838 from Abcam Category Protein Source E. coli Species Human

Human USP15 protein fragment - ab125983 from Abcam Category Protein Source E. coli Species Human

USP15 Antibody Blocking Peptide - LS-E3200 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP15 Antibody Blocking Peptide - LS-E25553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP15 Antibody Blocking Peptide - LS-E21698 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP15 Antibody Blocking Peptide - LS-E6892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP15 Recombinant Protein - H00009958-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human USP15 Protein - NBP2-22922 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

USP15 Peptide - P0939 from Novus Biologicals Category Peptide Species Human

USP15-Antibody-N-term-Blocking-Peptide - BP14352a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP15-Antibody-N-term-Blocking-Peptide - BP2143a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP15 blocking peptide - GTX24850-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Goat anti USP15 antibody Immunizing peptide - orb16764 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

USP15 Blocking Peptide - 33R-3459 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP15 protein (His tag) - 80R-2943 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

USP15 Peptide - AC21-0382-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

USP15 (1-235, His-tag) - AR51061PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

USP15 (1-235, His-tag) - AR51061PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

USP15 - H00009958-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP15 - H00009958-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP15, 1-235aa, Human, His tag, E.coli - 01-P2237 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

USP15 Peptide - 46-557P from ProSci Category Peptide Species Human

USP15 fusion protein - ag5712 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

USP15 fusion protein - Ag5703 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Search more