| Gene Symbol | H2AFY |
|---|---|
| Entrez Gene | 9555 |
| Alt Symbol | H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | H2A histone family, member Y |
| Other Description | core histone macro-H2A.1|histone H2A.y|histone macroH2A1|histone macroH2A1.1|histone macroH2A1.2|medulloblastoma antigen MU-MB-50.205 |
| Swissprots | Q96D41 O75367 Q7Z5E3 Q9UP96 Q9H8P3 Q503A8 O75377 |
| Accessions | EAW62218 EAW62219 EAW62220 EAW62221 EAW62222 O75367 AB209490 BAD92727 AF041483 AAC33433 AF044286 AAC33434 AF054174 AAC39908 AK023409 BAB14565 AK023833 AK092944 AK123153 AK296014 BAG58785 AY134746 AAN08620 BC013331 AAH13331 BC045570 BC063638 BC095406 AAH95406 BE262597 EU446955 ABZ92484 JF432887 ADZ16104 XM_005272132 XP_005272189 XM_005272134 XP_005272191 XM_005272135 XP_005272192 XM_011543728 XP_011542030 XM_011543729 XP_011542031 XM_011543730 XP_011542032 XM_011543731 XP_011542033 XM_011543732 XP_011542034 XM_011543733 XP_011542035 XM_011543734 XP_011542036 XM_011543735 XP_011542037 XR_948306 XR_948307 XR_948308 XR_948309 XR_948310 XR_948311 NM_001040158 NP_001035248 NM_004893 NP_004884 NM_138609 NP_613075 NM_138610 NP_613258 |
| Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP- ribose, and may be involved in ADP-ribose-mediated chromatin modulation. {ECO:0000269|PubMed:12718888, ECO:0000269|PubMed:15 |
| Subcellular Location | Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9714746}. |
| Top Pathways | Systemic lupus erythematosus, Alcoholism |