H2AFY

Gene Symbol H2AFY
Entrez Gene 9555
Alt Symbol H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
Species Human
Gene Type protein-coding
Description H2A histone family, member Y
Other Description core histone macro-H2A.1|histone H2A.y|histone macroH2A1|histone macroH2A1.1|histone macroH2A1.2|medulloblastoma antigen MU-MB-50.205
Swissprots Q96D41 O75367 Q7Z5E3 Q9UP96 Q9H8P3 Q503A8 O75377
Accessions EAW62218 EAW62219 EAW62220 EAW62221 EAW62222 O75367 AB209490 BAD92727 AF041483 AAC33433 AF044286 AAC33434 AF054174 AAC39908 AK023409 BAB14565 AK023833 AK092944 AK123153 AK296014 BAG58785 AY134746 AAN08620 BC013331 AAH13331 BC045570 BC063638 BC095406 AAH95406 BE262597 EU446955 ABZ92484 JF432887 ADZ16104 XM_005272132 XP_005272189 XM_005272134 XP_005272191 XM_005272135 XP_005272192 XM_011543728 XP_011542030 XM_011543729 XP_011542031 XM_011543730 XP_011542032 XM_011543731 XP_011542033 XM_011543732 XP_011542034 XM_011543733 XP_011542035 XM_011543734 XP_011542036 XM_011543735 XP_011542037 XR_948306 XR_948307 XR_948308 XR_948309 XR_948310 XR_948311 NM_001040158 NP_001035248 NM_004893 NP_004884 NM_138609 NP_613075 NM_138610 NP_613258
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP- ribose, and may be involved in ADP-ribose-mediated chromatin modulation. {ECO:0000269|PubMed:12718888, ECO:0000269|PubMed:15
Subcellular Location Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:9714746}.
Top Pathways Systemic lupus erythematosus, Alcoholism

MacroH2A1 CRISPR/Cas9 KO Plasmid (h) - sc-411295 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 HDR Plasmid (h) - sc-411295-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 Double Nickase Plasmid (h) - sc-411295-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 Double Nickase Plasmid (h2) - sc-411295-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 CRISPR Activation Plasmid (h) - sc-411295-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 CRISPR Activation Plasmid (h2) - sc-411295-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 Lentiviral Activation Particles (h) - sc-411295-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 Lentiviral Activation Particles (h2) - sc-411295-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MacroH2A1 siRNA (h) - sc-91790 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MacroH2A1 shRNA Plasmid (h) - sc-91790-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MacroH2A1 shRNA (h) Lentiviral Particles - sc-91790-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Histone H2AY/macroH2A.1 RNAi - H00009555-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Histone H2AY/macroH2A.1 RNAi - H00009555-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

H2AFJ RNAi - H00055766-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

Histone H2AY/macroH2A.1 RNAi - H00009555-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU098621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9842 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9842 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05497 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05497

H2AFY siRNA (Human) - CRH6356 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

H2AFY - MBS8232213 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human H2AFY (NM_004893.2) - SHH309850 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human H2AFY(NM_001040158.1) - SHH112241 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human H2AFY(NM_138610.2) - SHH112265 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human H2AFY(NM_138609.2) - SHH112283 from Creative biogene

Category siRNA
Species Reactivities Human
Search more