| Gene Symbol |
PICK1
|
| Entrez Gene |
9463
|
| Alt Symbol |
PICK, PRKCABP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein interacting with PRKCA 1
|
| Other Description |
PRKCA-binding protein|protein interacting with C kinase 1|protein kinase C-alpha-binding protein
|
| Swissprots |
Q9NRD5 O95906 B3KS52
|
| Accessions |
EAW60207 EAW60208 EAW60209 EAW60210 EAW60211 EAW60212 EAW60213 Q9NRD5 AB026491 BAA89294 AF231710 AAF97502 AK000875 BAG50834 AK092818 BAG52614 AK222640 BAD96360 AK299684 BAG61591 AK308792 AK310629 AL049654 CAB41082 AL137355 BC017561 AAH17561 CB141073 CN482899 CR456550 CAG30436 CU013150 CAK54581 CU013438 CAK54880 DQ893110 ABM84036 DQ896384 ABM87383 XM_006724379 XP_006724442 XM_006724380 XP_006724443 XM_011530517 XP_011528819 XR_937962 NM_001039583 NP_001034672 NM_001039584 NP_001034673 NM_012407 NP_036539
|
| Function |
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:2040
|
| Subcellular Location |
Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|