PICK1

Gene Symbol	PICK1
Entrez Gene	9463
Alt Symbol	PICK, PRKCABP
Species	Human
Gene Type	protein-coding
Description	protein interacting with PRKCA 1
Other Description	PRKCA-binding protein|protein interacting with C kinase 1|protein kinase C-alpha-binding protein
Swissprots	Q9NRD5 O95906 B3KS52
Accessions	EAW60207 EAW60208 EAW60209 EAW60210 EAW60211 EAW60212 EAW60213 Q9NRD5 AB026491 BAA89294 AF231710 AAF97502 AK000875 BAG50834 AK092818 BAG52614 AK222640 BAD96360 AK299684 BAG61591 AK308792 AK310629 AL049654 CAB41082 AL137355 BC017561 AAH17561 CB141073 CN482899 CR456550 CAG30436 CU013150 CAK54581 CU013438 CAK54880 DQ893110 ABM84036 DQ896384 ABM87383 XM_006724379 XP_006724442 XM_006724380 XP_006724443 XM_011530517 XP_011528819 XR_937962 NM_001039583 NP_001034672 NM_001039584 NP_001034673 NM_012407 NP_036539
Function	Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:2040
Subcellular Location	Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.
Tissue Specificity	Ubiquitous.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PICK1 full length protein - ab131893 from Abcam Category Protein Source Wheat germ Species Human

Human PICK1 full length protein - ab202221 from Abcam Category Protein Source E. coli Species Human

Human PICK1 protein fragment - ab152990 from Abcam Category Protein Source Wheat germ Species Human

PICK1 peptide - ab4964 from Abcam Category Peptide

PICK1 Antibody Blocking Peptide - LS-E8666 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PICK1 Antibody Blocking Peptide - LS-E8667 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PICK1 Antibody Blocking Peptide - LS-E26189 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PICK1 Recombinant Protein - H00009463-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PICK1 Partial Recombinant Protein - H00009463-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PICK1 Peptide - P2198 from Novus Biologicals Category Peptide Species Human

PICK1 Peptide - P2197 from Novus Biologicals Category Peptide Species Human

PICK1-PRKCABP-Antibody-C-term-Blocking-peptide - BP7078b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PICK1-PRKCABP-Antibody-N-term-Blocking-peptide - BP7078a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PICK1 blocking peptide - GTX89265-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Human PICK1 protein - orb245242 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PICK1 protein (His tag) - 80R-4062 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

PICK1 Blocking Peptide - abx161194 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Monkey

PICK1 Peptide - AC21-1020-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PICK1 (1-415, His-tag) - AR51747PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

PICK1 (1-415, His-tag) - AR51747PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

PICK1 - H00009463-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PICK1 - H00009463-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PICK1 - H00009463-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PICK1 - H00009463-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PICK1 control peptide - SP5150CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

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