PICK1

Gene Symbol PICK1
Entrez Gene 9463
Alt Symbol PICK, PRKCABP
Species Human
Gene Type protein-coding
Description protein interacting with PRKCA 1
Other Description PRKCA-binding protein|protein interacting with C kinase 1|protein kinase C-alpha-binding protein
Swissprots Q9NRD5 O95906 B3KS52
Accessions EAW60207 EAW60208 EAW60209 EAW60210 EAW60211 EAW60212 EAW60213 Q9NRD5 AB026491 BAA89294 AF231710 AAF97502 AK000875 BAG50834 AK092818 BAG52614 AK222640 BAD96360 AK299684 BAG61591 AK308792 AK310629 AL049654 CAB41082 AL137355 BC017561 AAH17561 CB141073 CN482899 CR456550 CAG30436 CU013150 CAK54581 CU013438 CAK54880 DQ893110 ABM84036 DQ896384 ABM87383 XM_006724379 XP_006724442 XM_006724380 XP_006724443 XM_011530517 XP_011528819 XR_937962 NM_001039583 NP_001034672 NM_001039584 NP_001034673 NM_012407 NP_036539
Function Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:2040
Subcellular Location Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.
Tissue Specificity Ubiquitous.

PICK1 (B-6) - sc-365403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PICK1 (B-6): sc-365403. Western blot analysis of PICK1 expression in non-transfected: sc-117752 (A) and mouse PICK1 transfected: sc-122567 (B) 293T whole cell lysates.

PICK1 (A-8) - sc-166591 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PICK1 (A-8): sc-166591. Western blot analysis of PICK1 expression in non-transfected: sc-117752 (A) and mouse PICK1 transfected: sc-122567 (B) 293T whole cell lysates.

PICK1 (D-10) - sc-390479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PICK1 (D-10): sc-390479. Western blot analysis of PICK1 expression in human smooth muscle tissue extract.

PICK1 (H-300) - sc-11410 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PICK1 (H-300): sc-11410. Western blot analysis of PICK1 expression in SH-SY5Y whole cell lysate.

PICK1 (C-4) - sc-74592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PICK1 (C-4): sc-74592. Western blot analysis of PICK1 expression in non-transfected (A) and human PICK1 transfected (B) 293 whole cell lysates.

PICK1 (N-18) - sc-9539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PICK1 (N-18): sc-9539. Immunofluorescence staining of methanol-fixed SK-N-SH cells showing cytoplasmic localization.

PICK1 (F-10) - sc-166654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PICK1 (F-10): sc-166654. Western blot analysis of PICK1 expression in non-transfected: sc-117752 (A) and mouse PICK1 transfected: sc-122567 (B) 293T whole cell lysates.

Anti-PICK1 antibody - ab3420 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab3420 staining PICK1 in mouse Hippocampal neurons by Immunocytochemistry/ Immunofluorescence. Cells were fixed in paraformaldehyde and permeabilized in 0.1% saponin/PBS prior to blocking in 3% BSA for 1 hour at room temperature. The primary antibody was diluted 1/300 in 3% BSA, 0.1% saponin /PBS and incubated with the sample for 18 hours at 4 °C. The secondary antibody was Alexa Fluor® 455-conjugated Donkey anti-Rabbit polyclonal, diluted 1/1000.

Anti-PICK1 antibody - ab71721 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PICK1 antibody (ab71721) at 1/100 dilution + Y79 cell lysate at 12.5 µg

Anti-PICK1 antibody - ab56586 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56586 PICK1 antibody at 1ug/ml.

Anti-PICK1 antibody [EPR4129(2)] - ab109249 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4129(2)
All lanes : Anti-PICK1 antibody [EPR4129(2)] (ab109249) at 1/1000 dilutionLane 1 : Fetal brain tissue lysateLane 2 : HeLa cell lysateLane 3 : LnCaP cell lysateLane 4 : SH SY5Y cell lysate

Anti-PICK1 antibody [EPR4130(3)] - ab133773 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4130(3)
All lanes : Anti-PICK1 antibody [EPR4130(3)] (ab133773) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : LnCaP lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti Rabbit IgG at 1/2000 dilution

Anti-PICK1 antibody [S20-8] - ab105585 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone S20-8
Immunohistochemical detection of Pick1 in frozen sections of Mouse brain extract using ab105585.

Anti-PICK1 Antibody (N-Terminus, PE) - LS-C245332 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (C-Terminus, Azide-free, HRP) - LS-C247760 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (N-Terminus, Azide-free, HRP) - LS-C247761 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (N-Terminus) - LS-C328239 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (aa24-229, Biotin) - LS-C299476 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (aa24-229, FITC) - LS-C302976 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (C-Terminus) - LS-C328236 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (C-Terminus) - LS-C345699 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PICK1 Antibody with human Jurkat Whole Cell lysate.

Anti-PICK1 Antibody (aa24-229) - LS-C296105 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PICK1.

Anti-PICK1 Antibody - LS-C331510 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human rectum using PICK1 antibody at dilution of 1:200 (200x lens).

Anti-PICK1 Antibody (aa317-416) - LS-C9609 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody (aa1-18) - LS-C90261 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more