Mapt

Gene Symbol Mapt
Entrez Gene 29477
Alt Symbol Mtapt, RNPTAU, pTau
Species Rat
Gene Type protein-coding
Description microtubule-associated protein tau
Other Description PHF-tau|Tau microtubule-associated protein|neurofibrillary tangle protein|paired helical filament-tau
Swissprots P19332 Q63567 Q63677 Q9QW06
Accessions EDM06297 EDM06298 EDM06299 EDM06300 EDM06301 EDM06302 EDM06303 EDM06304 EDM06305 EDM06306 EDM06307 EDM06308 EDM06309 EDM06310 P19332 BC126095 AAI26096 BG373604 CA945776 CB556982 CB581821 CB615367 CB726905 CB744947 CO394225 CO394568 CO405139 CO405815 D30629 DQ177309 ABA02201 DY311887 M84156 AAA42204 X79321 CAA55889 XM_008768268 XP_008766490 XM_008768269 XP_008766491 XM_008768270 XP_008766492 XM_008768271 XP_008766493 XM_008768272 XP_008766494 XM_008768273 XP_008766495 XM_008768274 XP_008766496 XM_008768275 XP_008766497 XM_008768277 XP_008766499 XM_008768278 XP_008766500 XM_008768279 XP_008766501 XM_008768280 XP_008766502 XM_008768281 XP_008766503 XM_008768282 XP_008766504 NM_017212 NP_058908
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Subcellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue Specificity Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited areas of the CNS.
Top Pathways Alzheimer's disease, MAPK signaling pathway

Anti-Tau antibody [SMI-51] - ab28031 from Abcam

Prices $372.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone SMI-51

Anti-MAPT / Tau Antibody (HRP) - LS-C318513 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPT / Tau Antibody (Biotin) - LS-C318511 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPT / Tau Antibody (FITC) - LS-C318508 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPT / Tau Antibody - LS-C318514 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPT / Tau Antibody (phospho-Ser416) - LS-C205163 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of extract from rat brain, rat hippocampus and mouse brain using Tau (phospho-Ser416) antibody.

Tau Antibody - NBP2-25163 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Chicken
Clonality Polyclonal
Western Blot: Tau Antibody [NBP2-25163] - Stripe blot of crude rat brain extract. Tau protein is expressed as up to 9 different isoforms of different molecular weight and so appears as multiple closely spaced bands covering the region of the blot from 48kDa to 67kDa, with an additional band at 100kDa.

Tau [p Ser416] Antibody - NB110-93503 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Tau [p Ser416] Antibody [NB110-93503] - Rat brain homogenate showing specific immunolabeling of the ~59, 65, 68k Tau isoforms phosphorylated at Ser416(control). Imunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Phospho-Mapt-S416 Polyclonal Antibody - AP0294 from ABclonal

Prices $175.00, $300.00, $480.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extract from rat brain, rat hippocampus and mouse brain using Phospho-Mapt-S416 Antibody

Microtubule-associated protein tau Antibody - abx110456 from Abbexa

Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau Antibody (Biotin) - abx106177 from Abbexa

Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau Antibody (FITC) - abx107591 from Abbexa

Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau Antibody (HRP) - abx109009 from Abbexa

Host Rabbit
Clonality Polyclonal

Rabbit Anti-Tau Antibody - 168-10403 from RayBiotech

Host Rabbit

Rabbit Anti-Bovine MAPT - DS-PB-01328 from RayBiotech

Host Rabbit

Tau (phospho Ser416) Antibody - 50-270 from ProSci

Prices $350.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of rat brain homogenate showing specific immunolabeling of the ~59, 65, 68k Tau isoforms phosphorylated at Ser416 (control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Tau (phospho Ser416) Antibody - 79-518 from ProSci

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extract from rat brain, rat hippocampus and mouse brain using Tau (phospho-Ser416).

Tau Antibody - 79-698 from ProSci

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extract from rat brain and mouse brain tissue using TAU Antibody.

Anti-Phospho-MAPT antibody (Ser416) - STJ22273 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau, Polyclonal Antibody - MBS1491252 from MyBioSource

Prices $160.00, $235.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau, Polyclonal Antibody - MBS1489229 from MyBioSource

Prices $160.00, $235.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau, Polyclonal Antibody - MBS1491352 from MyBioSource

Prices $160.00, $235.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Microtubule-associated protein tau, Polyclonal Antibody - MBS1490118 from MyBioSource

Prices $160.00, $235.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Phospho-Mapt-S416 - AP0294 from NeoScientific

Prices $300.00, $480.00
Sizes 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Tau (Ser416) Antibody - 252587 from ABBIOTEC

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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