| Gene Symbol |
PPP2R3C
|
| Entrez Gene |
55012
|
| Alt Symbol |
C14orf10, G4-1, G5pr
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 2, regulatory subunit B'', gamma
|
| Other Description |
protein phosphatase subunit G5PR|rhabdomyosarcoma antigen MU-RMS-40.6A|rhabdomyosarcoma antigen Mu-RMS-40.6C|serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
|
| Swissprots |
D3DS98 Q6P4G2 Q5GJ55 Q9NWR9 Q5GJ56 B4DEN7 Q86TZ3 Q969Q6 D3DS97
|
| Accessions |
EAW65886 EAW65887 EAW65888 EAW65889 EAW65890 Q969Q6 AA603611 AK000651 BAA91308 AK225447 AK225512 AK293717 BAG57148 AK310700 AK311337 AY157304 AAO17045 AY157305 AAO17046 AY518535 AAT44532 AY518536 AY518537 AAT44533 BC006823 AAH06823 BC010293 AAH10293 BC012563 AAH12563 BC037797 BC063438 AAH63438 BC100021 BI546396 BX248043 CAD62352 DA617813 HQ447258 ADQ31745 XM_005267782 XP_005267839 XM_005267784 XP_005267841 XM_006720184 XP_006720247 XM_011536885 XP_011535187 NM_001305155 NP_001292084 NM_001305156 NP_001292085 NM_017917 NP_060387 NR_130972
|
| Function |
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells. {ECO:0000250|UniProtKB:Q9JK24, ECO:0000269|PubMed:24333728}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15820313}. Cytoplasm {ECO:0000269|PubMed:15820313}. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. {ECO:0000269|PubMed:15820313}.
|
| Tissue Specificity |
Ubiquitously expressed in brain and other tissues. {ECO:0000269|PubMed:12167160, ECO:0000269|PubMed:15820313}.
|
| Top Pathways |
mRNA surveillance pathway, Dopaminergic synapse, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway
|