MCOLN1

Gene Symbol MCOLN1
Entrez Gene 57192
Alt Symbol MG-2, ML4, MLIV, MST080, MSTP080, TRP-ML1, TRPM-L1, TRPML1
Species Human
Gene Type protein-coding
Description mucolipin 1
Other Description mucolipidin|mucolipidosis type IV protein|mucolipin-1
Swissprots Q7Z4F7 D6W647 Q9H4B3 Q9H292 Q9GZU1 Q9H4B5
Accessions AAG00798 AAG42242 EAW69031 EAW69032 EAW69033 EAW69034 Q9GZU1 AA831948 AF171088 AAQ13604 AF249319 AAG10422 AF287269 AAG00797 AJ293659 CAC07813 AJ293970 CAC08215 AK026102 BAB15360 AK222673 BAD96393 AK294330 BAG57602 AK310109 BC005149 AAH05149 DC356874 DQ891844 ABM82770 DQ895032 ABM85958 NM_020533 NP_065394
Function Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis. {ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed in adult and fetal tissues. {ECO:0000269|PubMed:10973263, ECO:0000269|PubMed:11013137, ECO:0000269|PubMed:11030752}.
Top Pathways Lysosome

mucolipin 1 (F-10) - sc-398868 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
mucolipin 1 (F-10): sc-398868. Western blot analysis of mucolipin 1 expression in non-transfected: sc-117752 (A) and human mucolipin 1 transfected: sc-171244 (B) 293T whole cell lysates.

mucolipin 1 (H-75) - sc-48745 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
mucolipin 1 (H-75): sc-48745. Western blot analysis of mucolipin 1 expression in non-transfected: sc-117752 (A) and human mucolipin 1 transfected: sc-171244 (B) 293T whole cell lysates.

mucolipin 1 (L-15) - sc-26266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
mucolipin 1 (L-15): sc-26266. Western blot analysis of mucolipin 1 expression in Jurkat whole cell lysate.

mucolipin 1 (M-13) - sc-26269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
mucolipin 1 (M-13): sc-26269. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Anti-Mucolipin 1 antibody - ab74857 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab74857 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab74857, 1/1000 dilutionl) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Mucolipin 1 antibody - ab65523 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Mucolipin 1 antibody - ab28508 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Mucolipin 1 antibody (ab28508) at 0.5 µg/ml + Jurkat cell lysateSecondaryRabbit Anti mucolipin 1 at 1/50000 dilution

Anti-Mucolipin 1 antibody - ab68843 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Mucolipin 1 antibody - ab104888 from Abcam

Host Goat
Clonality Polyclonal

Anti-Mucolipin 1 antibody - ab67287 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Mucolipin 1 antibody - Carboxyterminal end - ab67284 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (C-Terminus, HRP) - LS-C141865 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (C-Terminus, Biotin) - LS-C141862 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (C-Terminus, DY650) - LS-C141863 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (C-Terminus, DY488) - LS-C141864 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (aa531-560, FITC) - LS-C262859 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (C-Terminus, DY550) - LS-C141866 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (aa531-560, APC) - LS-C262858 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (aa531-560, AP) - LS-C262856 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (aa531-560, PE) - LS-C262861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody - LS-C308924 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (aa530-560) - LS-C322918 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCOLN1 / Mucolipin 1 Antibody (C-Terminus) - LS-C141861 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mucolipin-1 in mouse brain lysates.

Anti-MCOLN1 / Mucolipin 1 Antibody (aa531-560) - LS-C164098 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MCOLN1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-MCOLN1 / Mucolipin 1 Antibody (aa101-150) IHC-plus™ - LS-B159 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MCOLN1 / Mucolipin 1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B159 concentration 20 ug/ml.
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