Gene Symbol | FBXO7 |
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Entrez Gene | 25793 |
Alt Symbol | FBX, FBX07, FBX7, PARK15, PKPS |
Species | Human |
Gene Type | protein-coding |
Description | F-box protein 7 |
Other Description | F-box only protein 7 |
Swissprots | Q9UF21 B4DWX5 Q9UKT2 Q96HM6 Q5TGC4 B4DNB3 Q9Y3I1 Q5TI86 |
Accessions | EAW60023 EAW60024 EAW60025 EAW60026 Q9Y3I1 AF129537 AAF04471 AF233225 AAF67155 AK054739 AK226087 AK291972 BAF84661 AK297841 BAG60175 AK301716 BAG63187 AL050254 CAB43356 AM392740 CAL37618 BC008361 AAH08361 BC041004 BI821903 BQ326686 BU584368 BX362053 BX409547 BX648151 BX648220 BX648644 CAI46263 CR456491 CAG30377 CU013088 CAK54519 CU013376 CAK54818 EU176789 ABW03590 EU176790 ABW03591 XM_011530106 XP_011528408 NM_001033024 NP_001028196 NM_001257990 NP_001244919 NM_012179 NP_036311 |
Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. {ECO:0000269|PubMed:15145941, ECO:0000269|PubMed:16510124, ECO:0000269|PubMed:23933751}. |
Subcellular Location | Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria. |
FBXO7 (E-8) - sc-271763 from Santa Cruz Biotechnology
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FBXO7 (H-80) - sc-366851 from Santa Cruz Biotechnology
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FBXO7 (L-17) - sc-86448 from Santa Cruz Biotechnology
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FBXO7 (P-14) - sc-86450 from Santa Cruz Biotechnology
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Anti-FBXO7 antibody - ab84129 from Abcam
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Anti-FBXO7 antibody - ab167278 from Abcam
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Anti-FBXO7 antibody - ab57037 from Abcam
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Anti-FBXO7 antibody - ab154098 from Abcam
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Anti-FBXO7 Antibody (aa357-456) - LS-C307986 from LifeSpan Bioscience
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Anti-FBXO7 Antibody (C-Terminus) - LS-C102004 from LifeSpan Bioscience
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Anti-FBXO7 Antibody - LS-C307984 from LifeSpan Bioscience
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FBXO7 Antibody - NBP1-55051 from Novus Biologicals
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FBXO7 Antibody - NBP1-84713 from Novus Biologicals
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FBXO7 Antibody - H00025793-B01P from Novus Biologicals
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FBXO7 Antibody - NBP2-16452 from Novus Biologicals
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FBXO7 Polyclonal Antibody - bs-8489R from Bioss
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Anti-FBXO7 antibody produced in mouse - SAB1407251 from Sigma-Aldrich
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Monoclonal Anti-FBXO7 antibody produced in mouse - WH0025793M1 from Sigma-Aldrich
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Anti-FBXO7 antibody produced in rabbit - HPA032114 from Sigma-Aldrich
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FBXO7 antibody - middle region (ARP43128_P050) - ARP43128_P050 from Aviva Systems Biology
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FBXO7 antibody - GTX101986 from GeneTex
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FBXO7 antibody, Internal - GTX46925 from GeneTex
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FBXO7 antibody - 70R-2794 from Fitzgerald
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Anti -FBXO7 (F-box Only Protein 7, FBX7, FBX, FBX07, DKFZp686B08113, PARK15, PKPS) - 126707 from USBiological Life Science
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Anti -FBXO7 (F-box Only Protein 7, FBX7, FBX, FBX07, DKFZp686B08113, PARK15, PKPS) - 126708 from USBiological Life Science
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