FBXO7
| Gene Symbol | FBXO7 |
|---|---|
| Entrez Gene | 25793 |
| Alt Symbol | FBX, FBX07, FBX7, PARK15, PKPS |
| Species | Human |
| Gene Type | protein-coding |
| Description | F-box protein 7 |
| Other Description | F-box only protein 7 |
| Swissprots | Q9UF21 B4DWX5 Q9UKT2 Q96HM6 Q5TGC4 B4DNB3 Q9Y3I1 Q5TI86 |
| Accessions | EAW60023 EAW60024 EAW60025 EAW60026 Q9Y3I1 AF129537 AAF04471 AF233225 AAF67155 AK054739 AK226087 AK291972 BAF84661 AK297841 BAG60175 AK301716 BAG63187 AL050254 CAB43356 AM392740 CAL37618 BC008361 AAH08361 BC041004 BI821903 BQ326686 BU584368 BX362053 BX409547 BX648151 BX648220 BX648644 CAI46263 CR456491 CAG30377 CU013088 CAK54519 CU013376 CAK54818 EU176789 ABW03590 EU176790 ABW03591 XM_011530106 XP_011528408 NM_001033024 NP_001028196 NM_001257990 NP_001244919 NM_012179 NP_036311 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. {ECO:0000269|PubMed:15145941, ECO:0000269|PubMed:16510124, ECO:0000269|PubMed:23933751}. |
| Subcellular Location | Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria. |
FBXO7 CRISPR/Cas9 KO Plasmid (h) - sc-405960 from Santa Cruz Biotechnology
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FBXO7 HDR Plasmid (h) - sc-405960-HDR from Santa Cruz Biotechnology
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FBXO7 Double Nickase Plasmid (h) - sc-405960-NIC from Santa Cruz Biotechnology
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FBXO7 Double Nickase Plasmid (h2) - sc-405960-NIC-2 from Santa Cruz Biotechnology
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FBXO7 CRISPR Activation Plasmid (h) - sc-405960-ACT from Santa Cruz Biotechnology
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FBXO7 CRISPR Activation Plasmid (h2) - sc-405960-ACT-2 from Santa Cruz Biotechnology
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FBXO7 Lentiviral Activation Particles (h) - sc-405960-LAC from Santa Cruz Biotechnology
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FBXO7 Lentiviral Activation Particles (h2) - sc-405960-LAC-2 from Santa Cruz Biotechnology
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FBXO7 siRNA (h) - sc-75010 from Santa Cruz Biotechnology
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FBXO7 shRNA Plasmid (h) - sc-75010-SH from Santa Cruz Biotechnology
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FBXO7 shRNA (h) Lentiviral Particles - sc-75010-V from Santa Cruz Biotechnology
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FBXO7 RNAi - H00025793-R02 from Novus Biologicals
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FBXO7 RNAi - H00025793-R01 from Novus Biologicals
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MISSION® esiRNA - EHU009661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8567 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8567 from Sigma-Aldrich
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FBXO7 siRNA (Human) - CRH8498 from Cohesion Biosciences
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FBXO7 - MBS8227406 from MyBioSource
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shRNA set against Human FBXO7 (NM_012179.3) - SHH293417 from Creative biogene
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shRNA set against Human FBXO7(NM_001033024.1) - SHH053201 from Creative biogene
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shRNA set against Human FBXO7(NM_012179.3) - SHH053219 from Creative biogene
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FBXO7 CRISPR/Cas9 KO Plasmid (h2) - sc-405960-KO-2 from Santa Cruz Biotechnology
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FBXO7 HDR Plasmid (h2) - sc-405960-HDR-2 from Santa Cruz Biotechnology
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Human FBXO7 siRNA - orb269000 from Biorbyt
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FBXO7 shRNA Plasmid (Human) - CHH8498 from Cohesion Biosciences
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