| Gene Symbol |
BTF3
|
| Entrez Gene |
689
|
| Alt Symbol |
BETA-NAC, BTF3a, BTF3b, NACB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
basic transcription factor 3
|
| Other Description |
NAC-beta|RNA polymerase B transcription factor 3|nascent polypeptide-associated complex subunit beta|nascent-polypeptide-associated complex beta polypeptide|transcription factor BTF3
|
| Swissprots |
A8K510 Q76M56 Q13893 P20290
|
| Accessions |
AAA58398 EAW95723 EAW95724 EAW95725 EAW95726 EAW95727 EAW95728 P20290 AB062126 BAB93458 AK225964 AK291125 BAF83814 AK310919 BC008062 AAH08062 BC061913 BG182166 BT007120 AAP35784 BU661989 BX359147 DQ892976 ABM83902 DQ896224 ABM87223 X53280 CAA37375 X74070 CAA52200 NM_001037637 NP_001032726 NM_001207 NP_001198
|
| Function |
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10982809}. Nucleus {ECO:0000269|PubMed:10982809}. Note=The heterodimer with NACA is cytoplasmic.
|