NPR2

Gene Symbol NPR2
Entrez Gene 4882
Alt Symbol AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi
Species Human
Gene Type protein-coding
Description natriuretic peptide receptor 2
Other Description ANP-B|ANPR-B|GC-B|NPR-B|atrial natriuretic peptide B-type receptor|atrial natriuretic peptide receptor 2|atrial natriuretic peptide receptor type B|guanylate cyclase B|natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Swissprots Q4VAK7 B0ZBF2 B0ZBF3 Q8TA93 Q5TCV2 O60871 D3DRP3 D3DRP4 Q9UQ50 P20594
Accessions AAS20319 ACA05920 ACA05921 ACA05922 BAA81737 EAW58337 EAW58338 EAW58339 EAW58340 P20594 AJ005282 CAA06466 BC023017 AAH23017 BC166642 AAI66642 BQ446138 HG501990 HG501991 L13436 XM_005251478 XP_005251535 XM_005251479 XP_005251536 XM_006716778 XP_006716841 XM_011517889 XP_011516191 XM_011517890 XP_011516192 XM_011517891 XP_011516193 XM_011517892 XP_011516194 XM_011517893 XP_011516195 XM_011517894 XP_011516196 XM_011517895 XP_011516197 NM_003995 NP_003986 NM_000907
Function Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000269|PubMed:15146390, ECO:0000269|PubMed:1672777}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Purine metabolism

NPR-B (G-13) - sc-34422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NPR-B (H-80) - sc-25486 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NPR-B (H-80): sc-25486. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic and membrane staining of glandular cells.

NPR-B (C-19) - sc-16870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NPR-B (C-19): sc-16870. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing membrane staining of subset of neuronal cells.

NPR-B (C-15) - sc-34421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NPR-B (L-20) - sc-16869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NPR-B (N-15) - sc-34423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NPR-B (N-18) - sc-34424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Natriuretic Peptide Receptor B antibody - ab14357 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Natriuretic Peptide Receptor B antibody - ab55724 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab55724 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab55724, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43um..

Anti-Natriuretic Peptide Receptor B antibody - ab55718 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Natriuretic Peptide Receptor B antibody (ab55718) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human stomach.

Anti-Natriuretic Peptide Receptor B antibody - ab14157 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Natriuretic Peptide Receptor B antibody [1E4] - ab119102 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1E4
ab119101, at 5 µg/ml, staining Natriuretic Peptide Receptor B in Formalin-fixed, Paraffin-embedded Human Prostate tissue by Immunohistochemistry.

Anti-Natriuretic Peptide Receptor B antibody [EPR5719(2)] - ab139188 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5719(2)
Overlay histogram showing SH-SY5Y cells stained with ab139188 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab139188, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-NPRB / NPR2 Antibody (aa288-302) - LS-C37438 from LifeSpan Bioscience

Prices $365.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody - LS-C124223 from LifeSpan Bioscience

Prices $405.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody - LS-C37439 from LifeSpan Bioscience

Prices $365.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa288-302) - LS-C130974 from LifeSpan Bioscience

Prices $405.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa480-509, AP) - LS-C264635 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa480-509, APC) - LS-C264636 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa480-509, FITC) - LS-C264638 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa480-509, PE) - LS-C264640 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa480-509, Azide-free, HRP) - LS-C264639 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa480-509, Biotin) - LS-C264637 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (aa479-509) - LS-C323422 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NPRB / NPR2 Antibody (clone 2A6) IHC-plus™ - LS-B5482 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2A6
Anti-NPR2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5482 concentration 5 ug/ml.
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