Gene Symbol | NPR2 |
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Entrez Gene | 4882 |
Alt Symbol | AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi |
Species | Human |
Gene Type | protein-coding |
Description | natriuretic peptide receptor 2 |
Other Description | ANP-B|ANPR-B|GC-B|NPR-B|atrial natriuretic peptide B-type receptor|atrial natriuretic peptide receptor 2|atrial natriuretic peptide receptor type B|guanylate cyclase B|natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) |
Swissprots | Q4VAK7 B0ZBF2 B0ZBF3 Q8TA93 Q5TCV2 O60871 D3DRP3 D3DRP4 Q9UQ50 P20594 |
Accessions | AAS20319 ACA05920 ACA05921 ACA05922 BAA81737 EAW58337 EAW58338 EAW58339 EAW58340 P20594 AJ005282 CAA06466 BC023017 AAH23017 BC166642 AAI66642 BQ446138 HG501990 HG501991 L13436 XM_005251478 XP_005251535 XM_005251479 XP_005251536 XM_006716778 XP_006716841 XM_011517889 XP_011516191 XM_011517890 XP_011516192 XM_011517891 XP_011516193 XM_011517892 XP_011516194 XM_011517893 XP_011516195 XM_011517894 XP_011516196 XM_011517895 XP_011516197 NM_003995 NP_003986 NM_000907 |
Function | Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000269|PubMed:15146390, ECO:0000269|PubMed:1672777}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Purine metabolism |
NPR-B CRISPR/Cas9 KO Plasmid (h) - sc-401861 from Santa Cruz Biotechnology
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NPR-B HDR Plasmid (h) - sc-401861-HDR from Santa Cruz Biotechnology
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NPR-B Double Nickase Plasmid (h) - sc-401861-NIC from Santa Cruz Biotechnology
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NPR-B Double Nickase Plasmid (h2) - sc-401861-NIC-2 from Santa Cruz Biotechnology
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NPR-B CRISPR Activation Plasmid (h) - sc-401861-ACT from Santa Cruz Biotechnology
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NPR-B CRISPR Activation Plasmid (h2) - sc-401861-ACT-2 from Santa Cruz Biotechnology
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NPR-B Lentiviral Activation Particles (h) - sc-401861-LAC from Santa Cruz Biotechnology
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NPR-B Lentiviral Activation Particles (h2) - sc-401861-LAC-2 from Santa Cruz Biotechnology
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NPR-B siRNA (h) - sc-40127 from Santa Cruz Biotechnology
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NPR-B shRNA Plasmid (h) - sc-40127-SH from Santa Cruz Biotechnology
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NPR-B shRNA (h) Lentiviral Particles - sc-40127-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086041 from Sigma-Aldrich
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MISSION® siRNA - SIHK1445 from Sigma-Aldrich
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MISSION® siRNA - SIHK1444 from Sigma-Aldrich
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MISSION® siRNA - SIHK1446 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2186 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2186 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02430 from Sigma-Aldrich
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NPR2 siRNA (Human) - CRH3243 from Cohesion Biosciences
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shRNA set against Human NPR2 (NM_003995.3) - SHH354404 from Creative biogene
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shRNA set against Human NPR2(NM_003995.3) - SHR018762 from Creative biogene
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NPR2 shRNA Plasmid (Human) - CHH3243 from Cohesion Biosciences
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NPR2 miRNA 3'UTR clone - MiUTR1H-06881 from Creative biogene
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