| Gene Symbol | APAF1 |
|---|---|
| Entrez Gene | 317 |
| Alt Symbol | APAF-1, CED4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | apoptotic peptidase activating factor 1 |
| Other Description | apoptotic protease-activating factor 1 |
| Swissprots | O43297 Q9UNC9 Q9UGN8 Q9UGN9 B2RMX8 Q9BXZ6 Q9UJ62 Q9UBZ5 Q7Z438 Q9UJ60 Q9UGP0 Q9UJ67 Q9UJ59 Q9UJ64 Q9UJ65 O14727 Q9UJ61 Q9UJ58 Q9UJ66 Q9UJ63 |
| Accessions | CAB65085 CAB65086 CAB65087 EAW97603 EAW97604 EAW97605 EAW97606 EAW97607 EAW97608 EAW97609 EAW97610 EAW97611 O14727 AB007873 BAA24843 AB103079 BAC77343 AF013263 AAC51678 AF134397 AAD38344 AF149794 AAD34016 AF248734 AAK28401 AJ243003 CAB55579 AJ243004 CAB55580 AJ243005 CAB55581 AJ243006 CAB55582 AJ243007 CAB55583 AJ243008 CAB55584 AJ243009 CAB55585 AJ243010 CAB55586 AJ243011 CAB55587 AJ243048 CAB55588 AJ243107 CAB56462 AK307509 BC136531 AAI36532 BC136532 AAI36533 BC150255 AAI50256 EF560718 ABQ59028 XM_011538252 XP_011536554 XM_011538253 XP_011536555 XM_011538254 XP_011536556 XM_011538255 XP_011536557 XR_429095 NM_001160 NP_001151 NM_013229 NP_037361 NM_181861 NP_863651 NM_181868 NP_863658 NM_181869 NP_863659 |
| Function | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12804598}. |
| Tissue Specificity | Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. |
| Top Pathways | Apoptosis, Huntington's disease, Amyotrophic lateral sclerosis (ALS), Tuberculosis, Alzheimer's disease |
APAF-1 siRNA gene - orb219166 from Biorbyt
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Human APAF1 cDNA clone(NM_181861.1) - CDFG011996 from Creative Biomart
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Human APAF1 cDNA clone(NM_181869.1) - CDFG011998 from Creative Biomart
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Human APAF1 cDNA clone(NM_181868.1) - CDFG012001 from Creative Biomart
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Human APAF1 cDNA clone(NM_001160.2) - CDFH000928 from Creative Biomart
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Human APAF1 cDNA clone(NM_013229.2) - CDFH000929 from Creative Biomart
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Human Apaf1 ORF clone(NM_181861.1) - CDCH015915 from Creative Biomart
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Human APAF1 ORF Clone(NM_013229.2) - CDCR296179 from Creative Biomart
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Human APAF1 ORF Clone(NM_013229.2) - CDCR296180 from Creative Biomart
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Human APAF1 ORF Clone(NM_181868.1) - CDCR324123 from Creative Biomart
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Human APAF1 ORF Clone(NM_181868.1) - CDCR324124 from Creative Biomart
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Human APAF1 ORF Clone(NM_181869.1) - CDCR324125 from Creative Biomart
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Human APAF1 ORF Clone(NM_181869.1) - CDCR324126 from Creative Biomart
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Human APAF1 ORF Clone(NM_181861.1) - CDCR324295 from Creative Biomart
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Human APAF1 ORF Clone(NM_181861.1) - CDCR324296 from Creative Biomart
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Human APAF1 ORF Clone(NM_001160.2) - CDCR353786 from Creative Biomart
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Human APAF1 ORF Clone(NM_001160.2) - CDCR353791 from Creative Biomart
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Human APAF1 ORF Clone(NM_001160.2) - CDCR353786 from Creative biogene
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Human APAF1 ORF clone (NM_013229.2) - CDCR028632 from Creative biogene
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Human APAF1 ORF clone (NM_181861.1) - CDCR028634 from Creative biogene
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Human APAF1 ORF clone (NM_181868.1) - CDCR028636 from Creative biogene
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Human APAF1 ORF clone (NM_181869.1) - CDCR028638 from Creative biogene
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Human APAF1 cDNA Clone(NM_181861.1) - CDFG011996 from Creative biogene
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Human APAF1 cDNA Clone(NM_181869.1) - CDFG011998 from Creative biogene
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Human APAF1 cDNA Clone(NM_181868.1) - CDFG012001 from Creative biogene
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