APAF1

Gene Symbol	APAF1
Entrez Gene	317
Alt Symbol	APAF-1, CED4
Species	Human
Gene Type	protein-coding
Description	apoptotic peptidase activating factor 1
Other Description	apoptotic protease-activating factor 1
Swissprots	O43297 Q9UNC9 Q9UGN8 Q9UGN9 B2RMX8 Q9BXZ6 Q9UJ62 Q9UBZ5 Q7Z438 Q9UJ60 Q9UGP0 Q9UJ67 Q9UJ59 Q9UJ64 Q9UJ65 O14727 Q9UJ61 Q9UJ58 Q9UJ66 Q9UJ63
Accessions	CAB65085 CAB65086 CAB65087 EAW97603 EAW97604 EAW97605 EAW97606 EAW97607 EAW97608 EAW97609 EAW97610 EAW97611 O14727 AB007873 BAA24843 AB103079 BAC77343 AF013263 AAC51678 AF134397 AAD38344 AF149794 AAD34016 AF248734 AAK28401 AJ243003 CAB55579 AJ243004 CAB55580 AJ243005 CAB55581 AJ243006 CAB55582 AJ243007 CAB55583 AJ243008 CAB55584 AJ243009 CAB55585 AJ243010 CAB55586 AJ243011 CAB55587 AJ243048 CAB55588 AJ243107 CAB56462 AK307509 BC136531 AAI36532 BC136532 AAI36533 BC150255 AAI50256 EF560718 ABQ59028 XM_011538252 XP_011536554 XM_011538253 XP_011536555 XM_011538254 XP_011536556 XM_011538255 XP_011536557 XR_429095 NM_001160 NP_001151 NM_013229 NP_037361 NM_181861 NP_863651 NM_181868 NP_863658 NM_181869 NP_863659
Function	Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12804598}.
Tissue Specificity	Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Top Pathways	Apoptosis, Huntington's disease, Amyotrophic lateral sclerosis (ALS), Tuberculosis, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

APAF1 peptide - ab2446 from Abcam Category Peptide

APAF1 peptide - ab7872 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

APAF1 peptide - ab7873 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human APAF1 full length protein - ab198064 from Abcam Category Protein Prices $858.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human APAF1 protein fragment - ab112251 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

APAF1 / APAF-1 Antibody Blocking Peptide - LS-E29868 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APAF1 / APAF-1 Antibody Blocking Peptide - LS-E29869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APAF-1 Partial Recombinant Protein - H00000317-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

APAF-1 Blocking Peptide - NBP1-76999PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

APAF-1 Blocking Peptide - NBP1-77000PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

APAF1 peptide - GTX22446 from GeneTex Category Peptide Prices $179.00 Sizes 500 μl Species Human

APAF1 peptide - GTX27872 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

APAF1 peptide - GTX27873 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

APAF-1 Blocking Peptide - abx161271 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

APAF-1 Blocking Peptide - abx062248 from Abbexa Category Peptide Species Human

APAF1 - H00000317-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

APAF1 - H00000317-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

APAF1 Control Peptide - AP30055CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

APAF1 Control Peptide - AP30056CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Recombinant Human APAF-1, HEK293 Lysate - 230-10042-100 from RayBiotech Category Protein Prices $154.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Apaf1 Peptide - 2015P from ProSci Category Peptide Species Human

Apaf1 Peptide - 2013P from ProSci Category Peptide Species Human

APAF1 fusion protein - ag17992 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

APAF1 fusion protein - ag16336 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Apoptotic Peptidase Activating Factor 1 (APAF1) - RPB054Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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