PINX1

Gene Symbol PINX1
Entrez Gene 54984
Alt Symbol LPTL, LPTS
Species Human
Gene Type protein-coding
Description PIN2/TERF1 interacting, telomerase inhibitor 1
Other Description 67-11-3 protein|PIN2 interacting protein 1|PIN2-interacting protein 1|PIN2/TERF1-interacting telomerase inhibitor 1|TRF1-interacting protein 1|hepatocellular carcinoma-related putative tumor suppressor|liver-related putative tumor suppressor|pin2-interacting protein X1|protein 67-11-3
Swissprots Q9NWW2 Q6QWG9 Q548A5 Q96BK5 Q9HBU7 Q96QD7 Q7Z7J8 B2R9B1
Accessions AAP12532 EAW65595 EAW65596 EAW65597 Q96BK5 AF205718 AAG18009 AF418553 AAN31333 AJ344104 CAC51436 AK313715 BAG36458 AY238941 AAP37006 AY523566 AAS19507 BC015479 AAH15479 BC043573 BC093762 AAH93762 BC143382 CB125276 NM_001284356 NP_001271285 NM_017884 NP_060354
Function Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.
Subcellular Location Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Tissue Specificity Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

PINX1 (D-3) - sc-374113 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PINX1 (D-3): sc-374113. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (A-8) - sc-374114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PINX1 (A-8): sc-374114. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (E-9) - sc-374115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PINX1 (E-9): sc-374115. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (H-8) - sc-376394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PINX1 (H-8): sc-376394. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (H-150) - sc-292115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PINX1 (H-150): sc-292115. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (N-13) - sc-67769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PINX1 (N-13): sc-67769. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (A-9) - sc-376588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PINX1 (A-9): sc-376588. Western blot analysis of PINX1 expression in non-transfected: sc-110760 (A) and human PINX1 transfected: sc-113229 (B) 293 whole cell lysates.

PINX1 (A-15) - sc-67765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PINX1 (A-15): sc-67765. Western blot analysis of PINX1 expression in Jurkat (A), A-431 (B), A549 (C) and K-562 (D) nuclear extracts.

Anti-PINX1 antibody - ab118255 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed paraffin embedded Human fetal colon tissue using ab118255 at 1/100, showing nuclear staining.

Anti-PINX1 antibody - ab190252 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of PINX1 in immunoprecipitates of Jurkat whole cell lysates (1 mg for IP, 20% of IP loaded) using ab190252 at 6 µg/reaction for IP and 1µg/ml for WB detection (Lane 1). Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-PINX1 antibody - ab2344 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PINX1 antibody - ab99112 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-PINX1 antibody (ab99112) at 0.3 µg/ml + HepG2 cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-PINX1 antibody - ab95208 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PINX1 antibody (ab95208) at 1/100 dilution + A375 cell line lysate at 35 µg

Anti-PINX1 antibody - ab111222 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded Human heart tissue, using ab111222 at a dilution of 1/50. Picture at the right with blocking peptide at 10 µg.

Anti-PINX1 antibody - N-terminal - ab194463 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-PINX1 antibody - N-terminal (ab194463) at 1/500 dilution + IMR-32 cell lysate at 50 µgdeveloped using the ECL technique

Anti-PINX1 Antibody - LS-C155457 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE PINX1 antibody diluted at 1:1000

Anti-PINX1 Antibody (aa121-170) - LS-C291266 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINX1 Antibody (aa35-84) - LS-C111964 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PINX1 antibody LS-C111964 Western blot of COLO205 cell lysate.

Anti-PINX1 Antibody (aa107-156) - LS-C117199 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PINX1 antibody LS-C117199 Western blot of HepG2 cell lysate.

Anti-PINX1 Antibody (aa2-15) - LS-C55286 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (2 ug/ml) of Jurkat lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-PINX1 Antibody (aa225-237) - LS-C108925 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PINX1 antibody (0.3 ug/ml) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PINX1 Antibody (aa21-281) - LS-C178669 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINX1 Antibody (aa225-275) - LS-C291025 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PINX1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-PINX1 antibody used for IP at 6 ug per reaction. PINX1 was also immunoprecipitated by rabbit anti-PINX1 antibody BL15294. For blotting immunoprecipitated PINX1, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

PINX1 Antibody - NBP1-83643 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PINX1 Antibody [NBP1-83643] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

PINX1 Antibody - NBP2-32265 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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