PINX1

Gene Symbol PINX1
Entrez Gene 54984
Alt Symbol LPTL, LPTS
Species Human
Gene Type protein-coding
Description PIN2/TERF1 interacting, telomerase inhibitor 1
Other Description 67-11-3 protein|PIN2 interacting protein 1|PIN2-interacting protein 1|PIN2/TERF1-interacting telomerase inhibitor 1|TRF1-interacting protein 1|hepatocellular carcinoma-related putative tumor suppressor|liver-related putative tumor suppressor|pin2-interacting protein X1|protein 67-11-3
Swissprots Q9NWW2 Q6QWG9 Q548A5 Q96BK5 Q9HBU7 Q96QD7 Q7Z7J8 B2R9B1
Accessions AAP12532 EAW65595 EAW65596 EAW65597 Q96BK5 AF205718 AAG18009 AF418553 AAN31333 AJ344104 CAC51436 AK313715 BAG36458 AY238941 AAP37006 AY523566 AAS19507 BC015479 AAH15479 BC043573 BC093762 AAH93762 BC143382 CB125276 NM_001284356 NP_001271285 NM_017884 NP_060354
Function Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.
Subcellular Location Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Tissue Specificity Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Human PINX1 ELISA Kit - E093631 from Biobool

Category ELISA Kit

anti-PINX1 antibody - ARG63195 from Arigo Biolaboratories

Category ELISA Kit

anti-PINX1 antibody - ARG65118 from Arigo Biolaboratories

Category ELISA Kit
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