SUMO2

Gene Symbol	SUMO2
Entrez Gene	6613
Alt Symbol	HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A
Species	Human
Gene Type	protein-coding
Description	small ubiquitin-like modifier 2
Other Description	SMT3 homolog 2|SMT3 suppressor of mif two 3 homolog 2|sentrin 2|small ubiquitin-related modifier 2|ubiquitin-like protein SMT3A|ubiquitin-like protein SMT3B
Swissprots	Q32Q42 Q6IPZ6 Q96HK1 B2R4I2 P61956
Accessions	EAW89249 EAW89250 P61956 AK024823 AK225090 AK225263 AK311837 BAG34779 BC008450 AAH08450 BC016775 AAH16775 BC022340 AAH22340 BC062713 AAH62713 BC068465 AAH68465 BC070159 AAH70159 BC071645 AAH71645 BC071646 AAH71646 BC107853 AAI07854 BF700114 BG778261 DQ893036 ABM83962 DQ896277 ABM87276 L76416 AAD45399 X99585 CAA67897 NM_001005849 NP_001005849 NM_006937 NP_008868
Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:9556629}.
Subcellular Location	Nucleus. Nucleus, PML body.
Tissue Specificity	Broadly expressed. {ECO:0000269|PubMed:9556629}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SUMO-2/3 (18H8) Rabbit mAb (HRP Conjugate) - 14066 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 18H8

SUMO-2/3 (18H8) Rabbit mAb - 4971 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 18H8

SUMO-2/3 Antibody - 4974 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

Anti-Sumo 2 antibody - ab66195 from Abcam Prices $370.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (Biotin) - LS-C343175 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C343172 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (N-Terminus) - LS-C98767 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (C-Terminus, Biotin) - LS-C270711 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C332112 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C332176 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (Gly93) - LS-C341184 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C341316 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C75737 from LifeSpan Bioscience Prices $560.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C10096 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (N-Terminus) - LS-C47088 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody - LS-C113059 from LifeSpan Bioscience Prices $315.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUMO2 Antibody - LS-C189195 from LifeSpan Bioscience Prices $425.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (aa44-93) IHC-plus™ - LS-B9279 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUMO2 Antibody (clone 973CT8.1.1) - LS-C203925 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Mouse Clonality Monoclonal Clone 973CT8.1.1

Anti-SUMO2 Antibody (C-Terminus) - LS-C98825 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

SUMO2 Antibody - NB100-56444 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

SUMO2/3/4 Antibody - AF3020 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

SUMO2 Antibody - NBP1-77163 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

SUMO2/3 Antibody (10F1) - NBP2-22546 from Novus Biologicals Prices $279.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 10F1

SUMO2/3 Antibody (SM23/496) - NBP2-34292 from Novus Biologicals Prices $129.00, $299.00, $429.00 Sizes 20 µg, 100 µg, 200 µg Host Mouse Clonality Monoclonal Clone SM23/496

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