PER2

Gene Symbol	PER2
Entrez Gene	8864
Alt Symbol	FASPS, FASPS1
Species	Human
Gene Type	protein-coding
Description	period circadian clock 2
Other Description	circadian clock protein PERIOD 2|hPER2|period 2|period circadian protein 2|period circadian protein homolog 2|period homolog 2
Swissprots	Q6DT41 Q9UQ45 Q4ZG49 A2I2P7 O15055
Accessions	AAT68170 AAX88976 ABM64216 EAW71153 EAW71154 EAW71155 O15055 AB002345 BAA20804 AB012614 BAA83709 AK294876 BAG57975 AK304108 BAG65011 BC111453 AAI11454 DA226434 XM_005246111 XP_005246168 XM_006712824 XP_006712887 NM_022817 NP_073728 NM_003894
Function	Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
Subcellular Location	Isoform 1: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:O54943}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization.
Tissue Specificity	Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). {ECO:0000269|PubMed:9427249}.
Top Pathways	Circadian rhythm, Herpes simplex infection, Circadian entrainment, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Per2 (H-90) - sc-25363 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Per2 (C-6) - sc-377290 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Per2 (N-19) - sc-7728 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Per2 (19-J6) - sc-101105 from Santa Cruz Biotechnology Prices $295.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-PER2 antibody - ab200388 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 antibody - ab180655 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PER2 antibody - ab118489 from Abcam Prices $376.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-PER2 antibody [EPR11381(2)] - ab179813 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11381(2)

Anti-PER2 Antibody (aa636-685) - LS-C199432 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (aa1-50) - LS-C289810 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (aa1010-1060) - LS-C148630 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (phospho-Ser662) - LS-C199433 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (aa1029-1040) IHC-plus™ - LS-B5121 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-PER2 Antibody (aa750-800) - LS-C148562 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (clone 5C10) IHC-plus™ - LS-B4477 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 5C10

Anti-PER2 Antibody - LS-C2836 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (C-Terminus) - LS-C17245 from LifeSpan Bioscience Prices $560.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody - LS-C90070 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (Biotin) - LS-C140812 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (DY488) - LS-C140814 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (DY650) - LS-C140813 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (HRP) - LS-C140815 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (DY550) - LS-C140816 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PER2 Antibody (C-Terminus) - LS-C110405 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PER2 Antibody - NB100-125 from Novus Biologicals Prices $99.00, $299.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

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