| Gene Symbol |
PER2
|
| Entrez Gene |
8864
|
| Alt Symbol |
FASPS, FASPS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
period circadian clock 2
|
| Other Description |
circadian clock protein PERIOD 2|hPER2|period 2|period circadian protein 2|period circadian protein homolog 2|period homolog 2
|
| Swissprots |
Q6DT41 Q9UQ45 Q4ZG49 A2I2P7 O15055
|
| Accessions |
AAT68170 AAX88976 ABM64216 EAW71153 EAW71154 EAW71155 O15055 AB002345 BAA20804 AB012614 BAA83709 AK294876 BAG57975 AK304108 BAG65011 BC111453 AAI11454 DA226434 XM_005246111 XP_005246168 XM_006712824 XP_006712887 NM_022817 NP_073728 NM_003894
|
| Function |
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
|
| Subcellular Location |
Isoform 1: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:O54943}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization.
|
| Tissue Specificity |
Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). {ECO:0000269|PubMed:9427249}.
|
| Top Pathways |
Circadian rhythm, Herpes simplex infection, Circadian entrainment, Transcriptional misregulation in cancer
|