PER2
| Gene Symbol | PER2 |
|---|---|
| Entrez Gene | 8864 |
| Alt Symbol | FASPS, FASPS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | period circadian clock 2 |
| Other Description | circadian clock protein PERIOD 2|hPER2|period 2|period circadian protein 2|period circadian protein homolog 2|period homolog 2 |
| Swissprots | Q6DT41 Q9UQ45 Q4ZG49 A2I2P7 O15055 |
| Accessions | AAT68170 AAX88976 ABM64216 EAW71153 EAW71154 EAW71155 O15055 AB002345 BAA20804 AB012614 BAA83709 AK294876 BAG57975 AK304108 BAG65011 BC111453 AAI11454 DA226434 XM_005246111 XP_005246168 XM_006712824 XP_006712887 NM_022817 NP_073728 NM_003894 |
| Function | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
| Subcellular Location | Isoform 1: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:O54943}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization. |
| Tissue Specificity | Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). {ECO:0000269|PubMed:9427249}. |
| Top Pathways | Circadian rhythm, Herpes simplex infection, Circadian entrainment, Transcriptional misregulation in cancer |
Per2 CRISPR/Cas9 KO Plasmid (h) - sc-401089 from Santa Cruz Biotechnology
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Per2 HDR Plasmid (h) - sc-401089-HDR from Santa Cruz Biotechnology
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Per2 Double Nickase Plasmid (h) - sc-401089-NIC from Santa Cruz Biotechnology
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Per2 Double Nickase Plasmid (h2) - sc-401089-NIC-2 from Santa Cruz Biotechnology
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Per2 CRISPR Activation Plasmid (h) - sc-401089-ACT from Santa Cruz Biotechnology
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Per2 CRISPR Activation Plasmid (h2) - sc-401089-ACT-2 from Santa Cruz Biotechnology
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Per2 Lentiviral Activation Particles (h) - sc-401089-LAC from Santa Cruz Biotechnology
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Per2 Lentiviral Activation Particles (h2) - sc-401089-LAC-2 from Santa Cruz Biotechnology
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Per2 siRNA (h) - sc-36209 from Santa Cruz Biotechnology
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Per2 shRNA Plasmid (h) - sc-36209-SH from Santa Cruz Biotechnology
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Per2 shRNA (h) Lentiviral Particles - sc-36209-V from Santa Cruz Biotechnology
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PER2 RNAi - H00008864-R01 from Novus Biologicals
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MISSION® esiRNA - EHU070571 from Sigma-Aldrich
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MISSION® esiRNA - EHU053181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16622 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16622 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00014 from Sigma-Aldrich
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PER2 siRNA (Human) - CRH5855 from Cohesion Biosciences
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Per2 CRISPR/Cas9 KO Plasmid (h2) - sc-401089-KO-2 from Santa Cruz Biotechnology
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Per2 HDR Plasmid (h2) - sc-401089-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PER2 (NM_022817.2) - SHH373548 from Creative biogene
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shRNA set against Human PER2(NM_022817.2) - SHR095646 from Creative biogene
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PER2 shRNA Plasmid (Human) - CHH5855 from Cohesion Biosciences
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PER2 miRNA 3'UTR clone - MiUTR1H-07784 from Creative biogene
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