| Gene Symbol |
KCTD13
|
| Entrez Gene |
253980
|
| Alt Symbol |
BACURD1, FKSG86, PDIP1, POLDIP1, hBACURD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel tetramerization domain containing 13
|
| Other Description |
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1|BTB/POZ domain-containing protein KCTD13|TNFAIP1-like protein|polymerase delta-interacting protein 1|potassium channel tetramerisation domain containing 13
|
| Swissprots |
Q96P93 A8K0R5 Q8WZ19 Q96SA1
|
| Accessions |
EAW79969 EAW79970 Q8WZ19 AF289573 AAL55757 AF401315 AAL14962 AK097407 AK289630 BAF82319 AY027918 AAK27301 BC036228 AAH36228 BI553707 DQ891555 ABM82481 DQ894742 ABM85668 XM_011545783 XP_011544085 XM_011545784 XP_011544086 XR_950767 XR_950768 NM_178863 NP_849194 NR_110933
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. {ECO:0000269|PubMed:19782033}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11593007}.
|
| Tissue Specificity |
Expressed in a wide variety of tissues. {ECO:0000269|PubMed:11593007}.
|
![Western Blot: POLDIP1 Overexpression Lysate (Adult Normal) [NBL1-12210] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for POLDIP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10192_POLDIP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12210-img0002.jpg)