Gene Symbol | KCTD13 |
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Entrez Gene | 253980 |
Alt Symbol | BACURD1, FKSG86, PDIP1, POLDIP1, hBACURD1 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel tetramerization domain containing 13 |
Other Description | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1|BTB/POZ domain-containing protein KCTD13|TNFAIP1-like protein|polymerase delta-interacting protein 1|potassium channel tetramerisation domain containing 13 |
Swissprots | Q96P93 A8K0R5 Q8WZ19 Q96SA1 |
Accessions | EAW79969 EAW79970 Q8WZ19 AF289573 AAL55757 AF401315 AAL14962 AK097407 AK289630 BAF82319 AY027918 AAK27301 BC036228 AAH36228 BI553707 DQ891555 ABM82481 DQ894742 ABM85668 XM_011545783 XP_011544085 XM_011545784 XP_011544086 XR_950767 XR_950768 NM_178863 NP_849194 NR_110933 |
Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. {ECO:0000269|PubMed:19782033}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11593007}. |
Tissue Specificity | Expressed in a wide variety of tissues. {ECO:0000269|PubMed:11593007}. |
KCTD13 CRISPR/Cas9 KO Plasmid (h) - sc-404120 from Santa Cruz Biotechnology
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KCTD13 HDR Plasmid (h) - sc-404120-HDR from Santa Cruz Biotechnology
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KCTD13 Double Nickase Plasmid (h) - sc-404120-NIC from Santa Cruz Biotechnology
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KCTD13 Double Nickase Plasmid (h2) - sc-404120-NIC-2 from Santa Cruz Biotechnology
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KCTD13 CRISPR Activation Plasmid (h) - sc-404120-ACT from Santa Cruz Biotechnology
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KCTD13 CRISPR Activation Plasmid (h2) - sc-404120-ACT-2 from Santa Cruz Biotechnology
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KCTD13 Lentiviral Activation Particles (h) - sc-404120-LAC from Santa Cruz Biotechnology
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KCTD13 Lentiviral Activation Particles (h2) - sc-404120-LAC-2 from Santa Cruz Biotechnology
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KCTD13 siRNA (h) - sc-75375 from Santa Cruz Biotechnology
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KCTD13 shRNA Plasmid (h) - sc-75375-SH from Santa Cruz Biotechnology
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KCTD13 shRNA (h) Lentiviral Particles - sc-75375-V from Santa Cruz Biotechnology
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POLDIP1 RNAi - H00253980-R01 from Novus Biologicals
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MISSION® esiRNA - EHU049651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11003 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11003 from Sigma-Aldrich
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KCTD13 siRNA (Human) - CRJ6661 from Cohesion Biosciences
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shRNA set against Human KCTD13 (NM_178863.3) - SHH323871 from Creative biogene
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KCTD13 shRNA Plasmid (Human) - CHJ6661 from Cohesion Biosciences
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KCTD13 miRNA 3'UTR clone - MiUTR3H-10325 from Creative biogene
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