| Gene Symbol |
KATNB1
|
| Entrez Gene |
10300
|
| Alt Symbol |
KAT, LIS6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
katanin p80 (WD repeat containing) subunit B 1
|
| Other Description |
katanin (80 kDa)|katanin p80 (WD40-containing) subunit B 1|katanin p80 WD40 repeat-containing subunit B1|katanin p80 WD40-containing subunit B1|katanin p80 subunit B1|p80 katanin
|
| Swissprots |
A6NCG6 O60620 Q9BVA0
|
| Accessions |
EAW82950 EAW82951 EAW82952 Q9BVA0 AB209250 BAD92487 AF052432 AAC09328 BC001353 AAH01353 BT007022 AAP35668 BU501165 CA306372 CR456762 CAG33043 DQ890767 ABM81693 XM_005255772 XP_005255829 XM_006721121 XP_006721184 XM_006721122 XP_006721185 XM_006721123 XP_006721186 XM_011522810 XP_011521112 NM_005886 NP_005877
|
| Function |
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
|